Skip Navigation

Schizophrenia Bulletin 1995 21(3):451-461; doi:10.1093/schbul/21.3.451
© 1995 by Oxford University Press and the Maryland Psychiatric Research Center (MPRC)
This Article
Right arrow FREE Full Text (PDF) Freely available
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Google Scholar
Right arrow Articles by Sachdev, P.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Sachdev, P.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

© Oxford University Press

This article appears in the following Schizophrenia Bulletin issue: Featured Topics: Psychosocial Factors and Medication Side Effects [View the issue table of contents]

The Epidemiology of Drug-induced Akathisia: Part II. Chronic, Tardive, and Withdrawal Akathisias

Perminder Sachdev
University of New South Wales, School of Psychiatry, Neuropsychiatric Institute, The Prince Henry Hospital Sydney, Australia

Reprint requests should be sent to Dr. P. Sachdev, Neuropsychiatric Institute, The Prince Henry Hospital, P.O. Box 233, Matraville, NSW 2036, Australia

This article examines the epidemiological data on chronic akathisia, tardive akathisia, and withdrawal akathisia. The limitations of the data are discussed— in particular, the lack of consistent definitions of the syndromes. The studies suggest that a significant proportion of patients chronically treated with neuroleptics suffer from akathisia. The prevalence may be as high as 40 percent, although a conservative estimate would be closer to 30 percent. Risk factors for the development of chronic akathisia and tardive akathisia are poorly understood, but old age, female sex, iron deficiency, negative symptoms, cognitive dysfunction, and affective disorder diagnosis need to be studied further for their potential role. While there is convincing evidence that akathisia may develop after neuroleptic cessation or reduction in dose, the prevalence and risk factors for withdrawal akathisia are not known. Reports of akathisia in children and the elderly have been few, and more systematic research is necessary. Akathisia appears to be common in individuals with mental retardation treated chronically with neuroleptics.


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 Journal of Pharmacy PracticeHome page
K. L. Claxton, J. J. Chen, and D. M. Swope
Drug-Induced Movement Disorders
Journal of Pharmacy Practice, December 1, 2007; 20(6): 415 - 429.
[Abstract] [PDF]

Home page
 Am. J. PsychiatryHome page
I. M. Bratti, J. M. Kane, and S. R. Marder
Chronic Restlessness With Antipsychotics
Am J Psychiatry, November 1, 2007; 164(11): 1648 - 1654.
[Full Text] [PDF]

Home page
 J PsychopharmacolHome page
R. Tranter and D. Healy
Neuroleptic discontinuation syndromes
J Psychopharmacol, January 1, 1998; 12(4): 401 - 406.
[Abstract] [PDF]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.