© 1998 by Oxford University Press and the Maryland Psychiatric Research Center (MPRC)
Predictors of Relapse and Rehospitalization in Schizophrenia and Schizoaffective Disorder
Senior Resident
Professor, Department of Psychological Medicine and Psychotherapy, Leopold-Franzens Universität Innsbruck, Austria
Biologist and Research Assistant, Department of Medical Informatics and Biomathematics, Westfälische-Wilhelms-Universität Münster, Germany
Professor, Department of Medical Informatics and Biomathematics, Westfälische-Wilhelms-Universität Münster, Germany
Professors, Department of Psychiatry, Freie Universität Berlin Germany
Professors, Department of Psychiatry, Freie Universität Berlin Germany
Professor, Department of Psychiatry, Heinrich Heine-Universität Düsseldorf, Germany
Professor, Georg-August-Universität Göttingen, Germany
Professor, Department of Psychiatry, Universität Basel Switzerland
Associate Professor, Park-Krankenhaus Leipzig-Dösen, Germany
Reprint requests should be Sent to Dr. S. Doering, Dept. of Psychological Medicine and Psychotherapy, University of Innsbruck, Sonnenburgstr. 9, 6020 Innsbruck, Austria
In a German multicenter treatment study, 354 patients with schizophrenia and schizoaffective disorder were followed for 2 years. The data collected were taken as a basis for the present predictor study. For the first time, the technique of classification and regression tree (CART) analysis has been employed for this purpose. CART yielded informative data and appeared to be a useful instrument in predictor research. On the out come variables "relapse" and "rehospitalization," significant predictor variables were found in several areas: neuroleptic treatment, onset and previous course (precipitating factors, first manifestation, hospitalization in the preceding year, suicide attempts), psychopathology (residual type, schizoaffective disorder), social adjustment (marital status, employment, intensity of life, Phillips score), previous life experiences (traumatic experiences and psychiatric or developmental disturbances in childhood), and biology (gender, age). Our investigation confirmed the gener ally prevalent views regarding the value of neuroleptic treatment, the multifactorial etiology, and the vulnerability stress model of schizophrenia.
Keywords: Predictors / relapse / rehospitalization
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