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Schizophrenia Bulletin 1998 24(2):185-187;
© 1998 by Oxford University Press and the Maryland Psychiatric Research Center (MPRC)
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© Oxford University Press

New Models of the Pathophysiology of Schizophrenia: Editors' Introduction

John G. Csernansky, M.D. and Anthony A. Grace, Ph.D.
Gregory B. Couch Professor of Psychiatry and Neurobiology, Washington University School of Medicine, and Medical Director, Metropolitan St. Louis Psychiatric Center St. Louis, MO
Professor of Neuroscience and Psychiatry, University of Pittsburgh Pittsburgh, PA

Reprint requests should be sent to Dr. J.G. Csernansky, Dept. of Psychiatry, Box 8134, Washington University School of Medicine, St. Louis, MO 63110

New models of the pathogenesis of schizophrenia are presented. These models represent hypotheses intended to stimulate discussion and new experimentation. Each of the contributions approach the pathophysiology of schizophrenia from a unique perspective. Yet, all of them emphasize the integration of new advances in basic neuroscience, the functional neuroanatomy of schizophrenia, and information drawn from new biotechnologies, such as neuroimaging and molecular genetics, to provide unique insights into schizophrenia. In each case, the novel hypotheses proposed also illustrate the continuing need for a better understanding of the dynamic interaction between synaptic plasticity and neural circuitry to further our understanding of the human brain in health and disease.

Keywords: Dopamine / synaptic plasticity / neural circuitry / neuroimaging


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