© 1998 by Oxford University Press and the Maryland Psychiatric Research Center (MPRC)
Model Generation and Testing to Probe Neural Circuitry in the Cingulate Cortex of Postmortem Schizophrenic Brain
Director, Laboratory for Structural Neuroscience, McLean Hospital Belmont, MA
Reprint requests should be sent to Dr. F.M. Benes, McLean Hospital, 115 Mill St., Belmont, MA 02178
In the past decade, there has been increased interest in whether discreet alterations of neural circuitry might play a role in the pathophysiology of schizophrenia. In the absence of a readily identifiable histopathology, a variety of sophisticated neurobiological approaches is being applied to the study of this disorder. In one series of investigations, subtle abnormalities have been detected in the anterior cingulate cortex-layer II (ACCx-II) of schizophrenia patients. One of these studies suggested a reduction of nonpyramidal neurons in schizophrenia patients, and it was postulated that this change could give rise to a relative increase of dopaminergic inputs to the remaining gammaaminobutyric acid (GABA) cells. Although empiric evidence in support of this hypothesis was obtained, a subsequent post hoc analysis, described in this report, has suggested that this change could have occurred irrespective of whether GABA cells are reduced in number. A shift of cortical dopamine afferents from pyramidal to nonpyramidal neurons in ACCx-II seems to provide a more plausible explanation for such a "miswiring." These findings support critical use of model generation and testing as powerful tools for unraveling the nature of altered neural circuitry in postmortem schizophrenic brain.
Keywords: Brain / cingulate cortex / circuitry
CiteULike 
Connotea 
Del.icio.us What's this?
This article has been cited by other articles:
|
|
 |
|
  P. Fusar-Poli, M.R. Broome, P. Matthiasson, J.B. Woolley, A. Mechelli, L.C. Johns, P. Tabraham, E. Bramon, L. Valmaggia, S.C. Williams, et al. Prefrontal Function at Presentation Directly Related to Clinical Outcome in People at Ultrahigh Risk of Psychosis Schizophr Bull, August 7, 2009; (2009) sbp074v1. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. C. Welsh, A. C. Chen, and S. F. Taylor Low-Frequency BOLD Fluctuations Demonstrate Altered Thalamocortical Connectivity in Schizophrenia Schizophr Bull, November 5, 2008; (2008) sbn145v1. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Z. J Daskalakis, B. K Christensen, P. B Fitzgerald, B. Moller, S. I Fountain, and R. Chen Increased cortical inhibition in persons with schizophrenia treated with clozapine J Psychopharmacol, March 1, 2008; 22(2): 203 - 209. [Abstract] [PDF]
|
|
|
|
|
|
S. J. Wood, C. Pantelis, D. Velakoulis, M. Yucel, A. Fornito, and P. D. McGorry Progressive Changes in the Development Toward Schizophrenia: Studies in Subjects at Increased Symptomatic Risk Schizophr Bull, March 1, 2008; 34(2): 322 - 329. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Williamson Are Anticorrelated Networks in the Brain Relevant to Schizophrenia? Schizophr Bull, July 1, 2007; 33(4): 994 - 1003. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. E. Jensen, J. Miller, P. C. Williamson, R. W. J. Neufeld, R. S. Menon, A. Malla, R. Manchanda, B. Schaefer, M. Densmore, and D. J. Drost Focal changes in brain energy and phospholipid metabolism in first-episode schizophrenia: 31P-MRS chemical shift imaging study at 4 Tesla The British Journal of Psychiatry, May 1, 2004; 184(5): 409 - 415. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Heckers, A. P. Weiss, T. Deckersbach, D. C. Goff, R. J. Morecraft, and G. Bush Anterior Cingulate Cortex Activation During Cognitive Interference in Schizophrenia Am J Psychiatry, April 1, 2004; 161(4): 707 - 715. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. L. Sobell, M. J. Mikesell, and C. T. McMurray Genetics and Etiopathophysiology of Schizophrenia Mayo Clin. Proc., October 1, 2002; 77(10): 1068 - 1082. [Abstract] [PDF]
|
|
|
|
 |
|
 D. A. Lewis Is There a Neuropathology of Schizophrenia? Recent Findings Converge on Altered Thalamic-Prefrontal Cortical Connectivity Neuroscientist, June 1, 2000; 6(3): 208 - 218. [Abstract] [PDF]
|
|