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Schizophrenia Bulletin 1998 24(3):343-364;
© 1998 by Oxford University Press and the Maryland Psychiatric Research Center (MPRC)
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© Oxford University Press

Positron Emission Tomography Studies of Abnormal Glucose Metabolism in Schizophrenia

Monte S. Buchsbaum, M.D. and Erin A. Hazlett, Ph.D.
Professor of Psychiatry and Director of the Neuroscience PET Laboratory, Department of Psychiatry, Mount Sinai School of Medicine New York, NY
Research Assistant Professor, Department of Psychiatry, Mount Sinai School of Medicine New York, NY

Reprint requests should be sent to Dr. M.S. Buchsbaum, Dept. of Psychiatry, Box 1505, Mt. Sinai School of Medicine, 1 Gustave L. Levy Place, New York, NY 10029-6574

Schizophrenia, a devastating disease characterized by a combination of various types of disturbed behaviors, thoughts, and feelings, may likewise be heterogeneous in etiology. Recent advances in neuroscience and psychopharmacology have suggested a wide array of competing mechanisms that may be involved in schizophrenia, including but not limited to deficits in one or more neurotransmitters and second messenger systems (e.g., dopamine, serotonin, gamma-aminobutyric acid, glutamate, and noradrenalin), neurodevelopmental defects in brain circuitry, and viral infection. Psychiatric genetic studies indicate that schizophrenia is a disorder with multifactorial inheritance. Since cerebral metabolic activity reflects regional brain work for all neurotransmitter systems, imaging metabolism directly with fluorodeoxyglucose and indirectly with blood flow and hemoglobin oxygen saturation can provide information about the functional neuroanatomy of a deficit in individual patients and allow patients to be grouped into more homogeneous subgroups for intensive study. This review summarizes metabolic imaging studies in schizophrenia over the past decade.

Keywords: Deoxyglucose / frontal lobe / thalamus / striatum / receptor ligands / brain imaging


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M. S. Buchsbaum, B. R. Buchsbaum, E. A. Hazlett, M. M. Haznedar, R. Newmark, C. Y. Tang, and P. R. Hof
Relative Glucose Metabolic Rate Higher in White Matter in Patients With Schizophrenia
Am J Psychiatry, July 1, 2007; 164(7): 1072 - 1081.
[Abstract] [Full Text] [PDF]


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