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Schizophrenia Bulletin 1999 25(2):321-335;
© 1999 by Oxford University Press and the Maryland Psychiatric Research Center (MPRC)
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© Oxford University Press

Glucose-Induced Increase in Memory Performance in Patients With Schizophrenia

John W. Newcomer, M.D., Suzanne Craft, Ph.D., Robert Fucetola, Ph.D., Steven O. Moldin, Ph.D., Gregg Selke, B.A., Leilani Paras, B.S. and Ryan Miller, B.A.
Assistant Professor, Departments of Psychiatry and Psychology, Washington University School of Medicine St. Louis, MO
Associate Professor, Department of Psychiatry and Behavioral Science, University of Washington, and Geriatric Research, Education & Clinical Center, Seattle/American Lake Veterans Affairs Medical Center Seattle, WA
Instructor, Department of Neurology, Washington University School of Medicine St. Louis, MO
StevenChief, Genetics Branch, National Institute of Mental Health Rockville, MD, and Department of Psychiatry, Georgetown University School of Medicine Washington, DC
Statistical Data Analyst, Department of Psychiatry, Washington University School of Medicine St. Louis, MO
medical student, University of Missouri Columbia, MO
medical student, Albany Medical College Albany, NY

Reprint requests should be sent to Dr. J.W. Newcomer, Dept. of Psychiatry, Washington University School of Medicine, 4940 Children's Place, St. Louis, MO 63110

Previous investigations have found that increasing circulating glucose availability can increase memory performance in rodents, healthy humans, and individuals with dementia of the Alzheimer's type. In this study, patients with schizophrenia, healthy control subjects, and controls with bipolar affective disorder were tested using double-blind treatment with either 50 g anhydrous dextrose plus 4 mg sodium saccharin (for "taste") or 23.7 mg saccharin alone, followed by cognitive testing on a complex battery. At this glucose dose, verbal memory performance on a paragraph recall task was increased during the glucose condition relative to the saccharin condition in the patients with schizophrenia; this effect was not detected in either the psychiatric or normal controls. The results provide preliminary support for the hypothesis that memory performance can be improved in patients with schizophrenia by increasing circulating glucose availability and suggest the importance of further evaluation of therapeutic manipulations of glucose availability.

Keywords: Cognition / glucose / learning


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