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Schizophrenia Bulletin 1999 25(3):601-607;
© 1999 by Oxford University Press and the Maryland Psychiatric Research Center (MPRC)
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© Oxford University Press

Altered Parallel Auditory Processing in Schizophrenia Patients

Eero Pekkonen, M.D., Ph.D., Minna Huotilainen, Ph.D., Heikki Katila, M.D., Ph.D., Jari Karhu, M.D., Ph.D., Risto Näätänen, Ph.D. and Jari Tühonen, M.D., Ph.D.
Researcher, Cognitive Brain Research Unit, Department of Psychology, University of Helsinki; Researcher, BioMag Laboratory, Medical Engineering Centre, Helsinki University Central Hospital; and Senior Physician, Department of Neurology, University of Helsinki Finland
Physicist, Cognitive Brain Research Unit, and Physicist, BioMag Laboratory
Senior Physician, Department of Psychiatry, University of Helsinki
Senior Physician, Department of Clinical Neurophysiology, University of Kuopio Finland
Professor, Department of Psychology, University of Helsinki
Professor, Department of Forensic Psychiatry, Niuvanniemi Hospital, University of Kuopio, and Consulting Physician, Department of Clinical Physiology, Kuopio University Hospital Finland

Reprint requests should be sent to Dr. Eero Pekkonen, BioMag Laboratory, PO Box 508, FIN-00029 HYKS, Finland

Patients with schizophrenia have impaired auditory processing that has been demonstrated by diminished P50 response to paired auditory stimuli in event-related potential (ERP) studies. Cerebral processing can also be studied with magnetoencephalography (MEG). With a whole-head MEG, which enables one to simultaneously measure brain activity in both hemispheres, we investigated whether early parallel auditory processing is impaired in schizophrenia. Sequences of tones were monaurally presented to schizophrenia patients and healthy controls in a passive condition, and the event-related magnetic fields were recorded simultaneously over both auditory cortices. The interhemispheric latency difference of the P50m, but not that of the N100m, was significantly shorter in the patient group in the right-ear but not in the left-ear stimulus condition. Further, the ipsilateral P50m was significantly earlier in schizophrenia patients in the right-ear condition. This result suggests that schizophrenia affects the consecutive preconscious auditory processing in a different manner.

Keywords: Magnetoencephalography / event-related potentials / P50 / N100 / schizophrenia


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