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Schizophrenia Bulletin 2000 26(2):257-273;
© 2000 by Oxford University Press and the Maryland Psychiatric Research Center (MPRC)
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© Oxford University Press

The Design of the Prenatal Determinants of Schizophrenia Study

Ezra S. Susser, M.D., Dr.Ph., Catherine A. Schaefer, Ph.D., Research Scientist, Alan S. Brown, M.D., Assistant Professor of Clinical Psychiatry, Melissa D. Begg, Sc.D. and Richard Jed Wyatt, M.D., Chief
Professor of Public Health (Epidemiology) and Psychiatry, and Head, Division of Epidemiology, Joseph L. Mailman School of Public Health, Columbia University, and Head, Division of Epidemiology of Brain Disorders, New York State Psychiatric Institute, College of Physicians and Surgeons, Columbia University New York, NY
Kaiser Permanente Research Division Oakland, CA
New York State Psychiatric Institute, College of Physicians and Surgeons Columbia University
Assistant Professor of Clinical Public Health (Biostatistics), Joseph L. Mailman School of Public Health, Columbia University
Neuropsychiatry Branch, National Institute of Mental Health Bethesda, MD

Send reprint requests to Dr. E. Susser, Joseph L. Mailman School of Public Health, Columbia University—Epidemiology Division, 600 West 168th St., PH18-119, New York, NY 10032; e-mail: ess8{at}columbia.edu

This paper describes the Prenatal Determinants of Schizophrenia (PDS) Study; three companion papers report the first results. The PDS Study was designed to study early antecedents of schizophrenia in a birth cohort of 1959–1967 for whom a wealth of archived prenatal data—including maternal sera—was available. Making use of the registries of a health plan into which the cohort was born, we ascertained and then diagnosed 71 cases of schizophrenia and spectrum disorders in the cohort. We describe herein the available prenatal data, the process of case diagnosis, and the strategies used to analyze prenatal determinants of schizophrenia in this cohort. Data are presented that bear on the main sources of potential bias and are important to understanding the strengths and limitations of this unique data set.

Keywords: Schizophrenia / epidemiology / prenatal


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