© 2000 by Oxford University Press and the Maryland Psychiatric Research Center (MPRC)
Incidence and Cumulative Risk of Treated Schizophrenia in the Prenatal Determinants of Schizophrenia Study
New York State Psychiatric Institute, College of Physicians and Surgeons, Columbia University New York, NY
New York State Psychiatric Institute, College of Physicians and Surgeons, Columbia University New York
Kaiser Permanente Research Division Oakland, CA
Joseph L. Mailman School of Public Health, Columbia University
Neuropsychiatry Branch, National Institute of Mental Health Bethesda, MD
Division of Epidemiology, Joseph L. Mailman School of Public Health, Columbia University and Head, Division of Epidemiology of Brain Disorders, New York State Psychiatric Institute, College of Physicians and Surgeons, Columbia University New York, NY
Reprint requests should be sent to Dr. M. Bresnahan, Epidemiology Division, Joseph L. Mailman School of Public Health, Columbia University 600 W. 168th St., PH 18-302, New York, NY 10032; e-mail: mab29{at}columbia.edu
The present study uses data from the Prenatal Determinants of Schizophrenia (PDS) Study to derive age- and sex-specific estimates of incidence and cumulative risk for DSM-IV schizophrenia. Although not designed as an incidence study, the PDS Study uses both a well-defined population under continuous followup and DSM-IV diagnoses. The originating cohort was established in Alameda County, California, during 1959–1967 and yielded 12,094 cohort members followed from 1981 to 1997 during the principal ages at risk for schizophrenia. Survival analytic techniques showed that schizophrenia incidence rates per 10,000 person-years for men were 9.4 for ages 15–19; 5.6 for ages 20–24; 3.3 for ages 25–29; and 0.9 for ages 30–34. Schizophrenia incidence rates per 10,000 person-years for women were 1.6 for ages 15–19; 1.3 for ages 20–24; and 4.1 for ages 25–29. The cumulative risk for schizophrenia by age 38 was 0.93 percent for men and 0.35 percent for women. These estimates of incidence rates and risk were higher than those in traditional incidence studies but similar to recent findings in other cohorts. Possible explanations for the apparently high rates of disorder include chance, design effects, and true variation in risk over time and place.
Keywords: Schizophrenia / incidence / cumulative risk
CiteULike 
Connotea 
Del.icio.us What's this?
This article has been cited by other articles:
|
|
 |
|
  A. S. Brown, S. Vinogradov, W. S. Kremen, J. H. Poole, R. F. Deicken, J. D. Penner, I. W. McKeague, A. Kochetkova, D. Kern, and C. A. Schaefer Prenatal Exposure to Maternal Infection and Executive Dysfunction in Adult Schizophrenia Am J Psychiatry, June 1, 2009; 166(6): 683 - 690. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Welham, M. Isohanni, P. Jones, and J. McGrath The Antecedents of Schizophrenia: A Review of Birth Cohort Studies Schizophr Bull, May 1, 2009; 35(3): 603 - 623. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. L. Waddington, A. S. Brown, A. Lane, C. A. Schaefer, R. R. Goetz, M. Bresnahan, and E. S. Susser Congenital anomalies and early functional impairments in a prospective birth cohort: risk of schizophrenia-spectrum disorder in adulthood The British Journal of Psychiatry, April 1, 2008; 192(4): 264 - 267. [Abstract] [Full Text] [PDF]
|
|