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Schizophrenia Bulletin 2000 26(2):479-493;
© 2000 by Oxford University Press and the Maryland Psychiatric Research Center (MPRC)
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© Oxford University Press

Simple Schizophrenia Revisited: A Clinical, Neuropsychological, and Neuroimaging Analysis of Nine Cases

Jordi Serra-Mestres, MRCPsych, Clinical Research Fellow, Carol A. Gregory, MRCPsych, Associate Specialist, Subash Tandon, M.B., Ch.B., Alison J. Stansfield, MRCPsych, Specialist Registrar, Paul M. Kemp, D.M., M.B., B.S., Consultant Psychiatrist and Peter J. McKenna, MRCPsych, Consultant in Nuclear Medicine
Institute of Neurology, Queen Square London, and Queen Mary and Westfield College, London, England
Fulbourn Hospital, Addenbrooke's NHS Trust Cambridge, England
Fulbourn Hospital, Addenbrooke's NHS Trust Cambridge, England
Southampton General Hospital Southampton, England

Send reprint requests to Dr. P.J. McKenna, Fulbourn Hospital, Addenbrooke's NHS Trust, Cambridge CB1 5EF, United Kingdom

Simple schizophrenia is widely considered to be a controversial or even discredited entity. However, cases showing typical clinical features continue to be identified in surveys of schizophrenia patients. This article reports on nine patients who met proposed diagnostic criteria for simple schizophrenia. The patients all showed the classical features of social and occupational decline, as well as negative symptoms in the absence of clear-cut positive symptoms. A range of other symptoms, which were either nonspecific or fell short of psychotic phenomena, was also seen. Neuropsychological testing revealed evidence of general intellectual impairment plus deficits in executive function and memory. Computed tomography scans were normal or showed only minor abnormalities. All patients, however, showed abnormalities on single photon emission computerized tomography (SPECT), mainly affecting frontal and temporal regions. It is concluded that cases conforming to the original descriptions of simple schizophrenia continue to be seen and are still best understood as representing a form of schizophrenia.

Keywords: Schizophrenia / subtypes / simple / neuropsychology / neuroimaging


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[Abstract] [Full Text] [PDF]


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