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Schizophrenia Bulletin 2000 26(3):543-549;
© 2000 by Oxford University Press and the Maryland Psychiatric Research Center (MPRC)
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© Oxford University Press

Intervention Research in Psychosis: Prevention Trials

Barry D. Lebowitz, Ph.D. and Jane L. Pearson
Chief, Adult and Geratric Treatment and Preventive Interventions, Research Branch Bethesda, MD
Associate Director for Preventive Interventions, Division of Services and Interventions Research, National Institute of Mental Health Bethesda, MD

Send reprint requests to Dr. B.D. Lebowitz, Adult and Geriatric Treatment and Preventive Interventions Research Branch, NIMH, 6001 Executive Blvd., Rm. 7160, MSC 9635, Bethesda, MD 20892-9635; e-mail: blebowit{at}mail.nih.gov

Prevention trials have not been a central focus in mental health research in general and in the psychoses in particular. In this article we provide the basis for development of a model for prevention trials, define the parameters of the model, and provide some illustrative examples. The article expands upon traditional approaches to prevention by incorporating perspectives from the fields of treatment and services research. Approaches to prevention are based upon models of etiology, pathophysiology, and risk. A number of barriers to the development of a major emphasis on prevention are identified, and those that are embedded in the infrastructure of the field are highlighted.

Keywords: Mental disorders / prevention / treatment / rehabilation / geriatrics


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