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Schizophrenia Bulletin 2000 26(3):709-721;
© 2000 by Oxford University Press and the Maryland Psychiatric Research Center (MPRC)
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© Oxford University Press

Altered Hemispheric Functional Dominance During Word Generation in Negative Schizophrenia

Eric Artiges, M.D., Ph.D., Jean-Luc Martinot, M.D., Ph.D., Maryse Verdys, M.D., Dominique Attar-Levy, M.D., Bernard Mazoyer, M.D., Ph.D., Nathalie Tzourio, M.D., Ph.D., Marie-José Giraud, M.D. and Marie-Laure Paillère-Martinot, M.D., Ph.D.
Psychiatrist, Orsay Hospital, and INSERM Unité 334 Service Hospitalier Frédéric Joliot, CEA France
Director of Research, INSERM Unité 334 Service Hospitalier Frédéric Joliot and Psychiatrist, Departments of Psychiatry France; and Bicêtre Hospital Le Kremlin-Bicètre, France
Psychiatrist, Ste. Anne Hospital Paris, France
Psychiatrist, Ste. Anne Hospital Paris, France
Professor, University of Caen, and Head, Functional Neuroimaging Group, Cyceron Center (CNRS FRE 2233 and CEA LRC 13) Caen, France
Director of Studies, CNRS FRE 2233, and CEA LRC 13, Caen
Psychiatrist, INSERM Unité 334
Psychiatrist, Department of Psychiatry, La Salpêtrière Hospital Paris, France

Send reprint requests to Dr. J.-L. Martinot, INSERM, Unite 334, SHFJ-DSV-DRM-CEA, 4 Place du Général Leclerc, 91401, Orsay, France; e-mail: maitinot{at}uriens.shfj.cea.fr

Functional brain imaging studies have reported decreased frontal activations in schizophrenia, but hemispheric dominance for language has rarely been assessed. To investigate regional activation and lateralization during word production, we determined normalized regional cerebral blood flow (rCBF) variations with positron emission tomography (PET) and H215O (water labeled with the isotope oxygen 15) in 14 negative schizophrenia patients and 14 volunteers. Subjects were scanned during two trials of three conditions: rest, vocalized verbal fluency, and spontaneous word production. Images were analyzed using an anatomical volumes of interest method, and the two groups' changes were compared, using rest as a baseline. Differences in the lateralization of changes were detected in homologous frontal and inferior parietal regions. The lateralization effects in patients arose from lower activations in the left frontal regions, abnormal right inferior frontal activations, and weaker right inferior parietal deactivation, during the word production tasks. The right hemisphere changes correlated negatively with the performance in verbal fluency. Thus in negative schizophrenia patients, while the activations were less focused on the left hemisphere regions usually engaged in word generation, rCBF changes in the right hemisphere might reflect a compensatory functional pattern.

Keywords: Schizophrenia / brain imaging / positron emission tomography / verbal fluency / language


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