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Schizophrenia Bulletin 2000 26(4):893-902;
© 2000 by Oxford University Press and the Maryland Psychiatric Research Center (MPRC)
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© Oxford University Press

Neuropsychological Deficit in Siblings Discordant for Schizophrenia

Mohamed Saoud, M.D., Ph.D., Psychiatrist, Thierry d'Amato, Pr., M.D, Ph.D., Professor of Psychiatry, Christel Gutknecht, Research Assistant, Pascal Triboulet, M.D., Medical Director and Psychiatrist, Jean-Pierre Bertaud, M.D., Psychiatrist, Michel Marie-Cardine, Pr., M.D., Professor of Psychiatry, Jean Daléry, Pr., M.D., Professor of Psychiatry and Thierry Rochet, M.D., Ph.D., Psychiatrist
Psychopathologie et Neurobiologie de la Schizophrénic et de la Vulnérabilité à la Psychose research group (EA 3092) at the University of Lyon I, Centre Hospitalier "Le Vinatier."
Psychopathologie et Neurobiologie de la Schizophrénic et de la Vulnérabilité à la Psychose research group (EA 3092) at the University of Lyon I, Centre Hospitalier "Le Vinatier."
Laboratoire de Biostatistique, Département d'Information Médicale, Hospices Civils de Lyon
Centre Hospitalier "Le Vinatier."
Centre Hospitalier "Le Vinatier."
Psychopathologie et Neurobiologie de la Schizophrénic et de la Vulnérabilité à la Psychose research group (EA 3092) at the University of Lyon I, Centre Hospitalier "Le Vinatier."
Psychopathologie et Neurobiologie de la Schizophrénic et de la Vulnérabilité à la Psychose research group (EA 3092) at the University of Lyon I, Centre Hospitalier "Le Vinatier."
Psychopathologie et Neurobiologie de la Schizophrénic et de la Vulnérabilité à la Psychose research group (EA 3092) at the University of Lyon I, Centre Hospitalier "Le Vinatier."

Send reprint requests to Pr. T. d'Amato, Centre Hospitalier "Le Vinatier," 95 Blvd. Pinel, F-69500 Bron, France; e-mail: thierry.damato{at}ch-le-vinatier.fr

This study was aimed, first, at detecting neuropsychological markers that assess vulnerability to schizophrenia in siblings of patients with schizophrenia, and second, at exploring possible relationships between markers. For these purposes, performances were assessed in 18 clinicaly stabilized patients with schizophrenia, 18 of their unaffected full siblings, and 15 controls on attentional abilities (the Degraded Stimuli-Continuous Performance Task [DS-CPT] and the Span of Apprehension [SOA] task) and on executive functions (the Wisconsin Card Sorting Test [WCST]). Both patients and siblings were impaired on the three tasks, leading to the conclusion that these poor performances may represent markers of genetic vulnerability to schizophrenia. Furthermore, significant relationships were found between DS-CPT and WCST performance in patients only, suggesting a possible implication of prefrontal brain areas for the two tasks. In spite of the lack of similar relationships between DS-CPT and WCST in siblings, this raises the question of a putative role of prefrontal areas in vulnerability to schizophrenia.

Keywords: Schizophrenia / vulnerability / siblings / first degree relatives / attention / executive functions


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