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Schizophrenia Bulletin 2001 27(3):395-416;
© 2001 by Oxford University Press and the Maryland Psychiatric Research Center (MPRC)
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© Oxford University Press

Challenges, Status, and Opportunities for Studying Developmental Neuropathology in Adult Schizophrenia

Steven E. Arnold, M.D., Associate Professor of Psychiatry and Neurology and Director and Lise Rioux, Ph.D., Research Associate
Laboratory for Cellular and Molecular Neuropathology, Center for Neurobiology and Behavior, University of Pennsylvania Philadelphia, PA.
Laboratory for Cellular and Molecular Neuropathology, Center for Neurobiology and Behavior, University of Pennsylvania Philadelphia, PA.

Send requests to Dr. S. E. Arnold, Center for Neurobiology and Behavior, 142 Clinical Research Building, 415 Curie Boulevard, Philadelphia, PA 19104; e-mail: sarnold{at}mail.med.upenn.edu

Neurodevelopmental theories of the pathoetiology of schizophrenia have been at the forefront of schizophrenia research in recent years. Support for these theories is substantial and growing. Epidemiological, phenomenological, and clinical neurobiological research have provided compelling though still circumstantial evidence. Neuropathological investigations also have provided some evidence; however, these have yet to actualize their potential for revealing the cellular and molecular nature of developmental aberrancies in this disease. This article summarizes the clinical evidence suggesting abnormal neurodevelopment in schizophrenia, outlines some of the important anatomic, cellular, and molecular mechanisms of normal central nervous system development, reviews current neuropathological findings relevant to neurodevelopment in schizophrenia, and suggests some new directions and opportunities for discovering the molecular neurodevelopmental basis of the disorder.

Keywords: Neurogenesis / migration / differentiation / synaptogenesis / cytoarchitecture


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