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Schizophrenia Bulletin 2001 27(3):417-430;
© 2001 by Oxford University Press and the Maryland Psychiatric Research Center (MPRC)
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© Oxford University Press

Genetic Insights Into the Neurodevelopmental Hypothesis of Schizophrenia

Anne S. Bassett, M.D., FRCPC, Associate Professor, Eva W.C. Chow, M.D., FRCPC, Assistant Professor, Sheri O'Neill, M.Sc., CCGC, Genetic Counselor and Linda M. Brzustowicz, M.D., Assistant Professor
Department of Psychiatry, University of Toronto, and Head, Genetics Section, Schizophrenia Research Program, Queen Street Division, Centre for Addiction and Mental Health Toronto, Ontario
Department of Psychiatry, University of Toronto and Centre for Addiction and Mental Health Toronto, Ontario
Schizophrenia Research Program, Queen Street Division, Centre for Addiction and Mental Health Toronto, Ontario
Department of Genetics, Rutgers University, Piscataway, and Department of Psychiatry, University of Medicine and Dentistry of New Jersey Newark/Piscataway, NJ

Send reprint requests to: Dr. A.S. Bassett, Schizophrenia Research Program, Queen Street Site, Centre for Addiction and Mental Health, 1001 Queen Street West, Toronto, Ontario, Canada, M6J 1H4; e-mail: anne.bassett{at}utoronto.ca

The original neurodevelopmental hypothesis of schizophrenia presented by D.R. Weinberger in 1987 focused on pathogenesis and did not address etiology. Available evidence indicates that genetic factors are the principal cause of schizophrenia. It is imperative that any pathogenetic model for schizophrenia takes into account what is now known about genetic mechanisms of illness. Recent advances in molecular genetics can provide insights into the neurodevelopmental expression of the illness and what future genetic discoveries are likely to contribute to our understanding of schizophrenia. In this article, we propose a genetic model of etiopathogenesis that is consistent both with a modified neurodevelopmental hypothesis and our current knowledge about schizophrenia and molecular genetics.

Keywords: neurodevelopment / schizophrenia / genetics / pathogenesis


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