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Schizophrenia Bulletin 2001 27(3):431-442;
© 2001 by Oxford University Press and the Maryland Psychiatric Research Center (MPRC)
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© Oxford University Press

Mesoprefrontal Dopamine Neurons and Schizophrenia: Role of Developmental Abnormalities

Janet M. Finlay, Ph.D., Assistant Professor
Department of Psychology, Western Washington University Bellingham, WA

Send reprint requests to Dr. J.M. Finlay, Department of Psychology, Western Washington University, 220 Miller Hall, Bellingham, WA 98225-9089; e-mail: janet.finlay{at}wwu.edu

Schizophrenia is characterized by a complex array of symptoms that include hallucinations, delusions, abnormal affect, and cognitive deficits. It is becoming increasingly apparent that the symptoms of the disorder are paralleled by equally complex functional and structural abnormalities in brain regions such as the temporal lobe, prefrontal cortex, and thalamus. In addition, the delayed onset of symptoms in late adolescence/early adulthood suggests that abnormal development of the nervous system may ultimately contribute to the neurobiology of the disorder. The present review focuses on clinical and basic research that, together, suggests abnormal development of the dopamine (DA) innervation of prefrontal cortex plays a role in the cognitive deficits of schizophrenia.

Keywords: Prefrontal cortex / cognitive deficits / development / basic research / clinical research / animal models


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