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Schizophrenia Bulletin 2001 27(3):497-502;
© 2001 by Oxford University Press and the Maryland Psychiatric Research Center (MPRC)
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© Oxford University Press

Disturbed Circadian Rest-Activity Cycles in Schizophrenia Patients: An Effect of Drugs?

Anna Wirz-Justice, Ph.D., Head, Hans-Joachim Haug, M.D., Deputy Medical Head and Christian Cajochen, Ph.D., Assistant Professor
Centre for Chronobiology, Psychiatric University Clinic Basel, Switzerland
Social Psychiatric Services, at the Psychiatric University Clinic Zurich, Switzerland
Center for Chronobiology, Psychiatric University Clinic Basel, Switzerland

Send reprint requests to Prof. A. Wirz-Justice, Centre for Chronobiology, Psychiatric University Clinic, Wilhelm Klein Str. 27, CH-4025 Basel, Switzerland; e-mail: anna.wirz-justice{at}unibas.ch

The circadian rest-activity cycle of schizophrenia patients stabilized for more than a year on monotherapy with a "classical" neuroleptic (haloperidol, flupentixol) or with the atypical neuroleptic clozapine was documented by continuous activity monitoring for 3–7 weeks. In this pilot study, the three patients treated with clozapine had remarkably highly ordered rest-activity cycles, whereas the four patients on classical neuroleptics had minor to major circadian rhythm abnormalities. This is the first documentation of circadian rest-activity cycle disturbances in schizophrenia related to class of drug.

Keywords: Circadian rest-activity cycle / schizophrenia / neuroleptics / clozapine


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