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Schizophrenia Bulletin 2003 29(4):791-801;
© 2003 by Oxford University Press and the Maryland Psychiatric Research Center (MPRC)
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© Oxford University Press

The Concept of Population Prevention: Application to Schizophrenia

Ramin Mojtabai, M.D., Ph.D., M.P.H., Assistant Professor of Clinical Psychiatry, Dolores Malaspina, M.D., M.S.P.H., Professor of Clinical Psychiatry and Ezra Susser, M.D., Dr.P.H., Professor of Clinical Psychiatry and Epidemiology
Department of Psychiatry and Mailman School of Public Health Columbia University

Send reprint requests to Dr. R. Mojtabai, 2600 Netherland Ave., Apt. 805, Bronx, NY 10463; e-mail: rm322{at}columbia.edu

There is currently a debate about the appropriate approach to prevention of schizophrenia. While many argue that prevention efforts should focus on individuals at high risk of developing the illness, others argue for interventions that would reduce the risk in the whole population. This article situates the debate in a historical context. We find its antecedents in a classic 1940s and 1950s debate between British physicians George Pickering and Robert Platt on hypertension and trace a line from Pickering to the influential concept of population prevention formulated by his student Geoffrey Rose. We then discuss the potential application of population prevention to schizophrenia. The article concludes that population and high-risk prevention strategies can be complementary and that it may be feasible and appropriate to use them in combination.

Keywords: Schizophrenia / preventive psychiatry / prevention / population prevention / primary prevention / high-risk strategy / secondary prevention


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L. J. PHILLIPS, P. D. McGORRY, A. R. YUNG, T. H. McGLASHAN, B. CORNBLATT, and J. KLOSTERKOTTER
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The British Journal of Psychiatry, August 1, 2005; 187(48): s33 - s44.
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