Skip Navigation

Schizophrenia Bulletin 2004 30(3):627-647;
© 2004 by Oxford University Press and the Maryland Psychiatric Research Center (MPRC)
This Article
Right arrow FREE Full Text (PDF) Freely available
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Google Scholar
Right arrow Articles by Miller, A. L.
Right arrow Articles by Shon, S.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Miller, A. L.
Right arrow Articles by Shon, S.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

© Oxford University Press

The Texas Medication Algorithm Project: Clinical Results for Schizophrenia

Alexander L. Miller, M.D., Professor, M. Lynn Crismon, Pharm.D., Professor, A. John Rush, M.D., Professor, John Chiles, M.D., Professor, T. Michael Kashner, Ph.D., J.D., Professor, Marcia Toprac, Ph.D., Director, Thomas Carmody, Ph.D., Assistant Professor, Melanie Biggs, Ph.D., Assistant Professor, Kathy Shores-Wilson, Ph.D., Assistant Professor, Judith Chiles, R.N., Brad Witte, B.S., Research Nurse, Christine Bow-Thomas, Ph.D., Senior Research Associate, Dawn I. Velligan, Ph.D., Clinical Psychologist, Madhukar Trivedi, M.D., Professor, Trisha Suppes, M.D., Ph.D., Associate Professor and Steven Shon, M.D., Medical Director
Department of Psychiatry, University of Texas Health Science Center at San Antonio San Antonio, TX and Director of Clinical Research, San Antonio State Hospital San Antonio, TX
Pharmacy Practice and Administration, University of Texas at Austin College of Pharmacy Austin, TX and Clinical Psychopharmacologist, Texas Department of Mental Health and Mental Retardation Austin, TX
Department of Psychiatry, University of Texas Southwestern Medical Center at Dallas Dallas, TX
, Department of Psychiatry, University of Texas Health Science Center at San Antonio at the time of this research and is currently Clinical Professor, Department of Psychiatry, University of Washington Seattle, WA
Department of Psychiatry, University of Texas Southwestern Medical Center at Dallas, and VA HSR&D Research Career Scientist
Office of Research and Education, Texas Department of Mental Health and Mental Retardation
Department of Psychiatry, University of Texas Southwestern Medical Center at Dallas
Department of Psychiatry, University of Texas Southwestern Medical Center at Dallas
Department of Psychiatry, University of Texas Southwestern Medical Center at Dallas
San Antonio State Hospital
Department of Psychiatry, University of Texas Southwestern Medical Center at Dallas
San Antonio State Hospital
Department of Psychiatry, University of Texas Health Science Center at San Antonio
Department of Psychiatry, University of Texas Southwestern Medical Center at Dallas
Texas Department of Mental Health and Mental Retardation

Send reprint requests to Dr. A.L. Miller, Department of Psychiatry, MS 7792, University of Texas Health Science Center at San Antionio, 7703 Floyd Curl Drive, San Antonio, TX 78229–3900; e-mail: millera{at}uth-scsa.edu

In the Texas Medication Algorithm Project (TMAP), patients were given algorithm-guided treatment (ALGO) or treatment as usual (TAU). The ALGO intervention included a clinical coordinator to assist the physicians and administer a patient and family education program. The primary comparison in the schizophrenia module of TMAP was between patients seen in clinics in which ALGO was used (n=165) and patients seen in clinics in which no algorithms were used (n=144). A third group of patients, seen in clinics using an algorithm for bipolar or major depressive disorder but not for schizophrenia, was also studied (n=156). The ALGO group had modestly greater improvement in symptoms (Brief Psychiatric Rating Scale) during the first quarter of treatment. The TAU group caught up by the end of 12 months. Cognitive functions were more improved in ALGO than in TAU at 3 months, and this difference was greater at 9 months (the final cognitive assessment). In secondary comparisons of ALGO with the second TAU group, the greater improvement in cognitive functioning was again noted, but the initial symptom difference was not significant.

Keywords: Algorithm / guideline / medication / schizophrenia / symptoms


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 Psychiatr. Serv.Home page
K. K. Milner, D. Healy, K. L. Barry, F. C. Blow, C. Irmiter, and P. De Chavez
State Mental Health Policy: Implementation of Computerized Medication Prescribing Algorithms in a Community Mental Health System
Psychiatr Serv, August 1, 2009; 60(8): 1010 - 1012.
[Abstract] [Full Text] [PDF]

Home page
 Schizophr BullHome page
R. E. Drake, G. R. Bond, and S. M. Essock
Implementing Evidence-Based Practices for People With Schizophrenia
Schizophr Bull, July 1, 2009; 35(4): 704 - 713.
[Abstract] [Full Text] [PDF]

Home page
 Schizophr BullHome page
R. Mojtabai, L. Fochtmann, S.-W. Chang, R. Kotov, T. J. Craig, and E. Bromet
Unmet Need for Mental Health Care in Schizophrenia: An Overview of Literature and New Data From a First-Admission Study
Schizophr Bull, July 1, 2009; 35(4): 679 - 695.
[Abstract] [Full Text] [PDF]

Home page
 Psychiatr. Serv.Home page
V. Ganju
State Mental Health Policy: Mental Health Transformation: Moving Toward a Public Health, Early-Intervention Approach in Texas
Psychiatr Serv, January 1, 2008; 59(1): 17 - 20.
[Abstract] [Full Text] [PDF]

Home page
 Psychiatr. Serv.Home page
D. I. Velligan, M. Wang, P. Diamond, D. C. Glahn, D. Castillo, S. Bendle, Y. W. F. Lam, L. Ereshefsky, and A. L. Miller
Relationships Among Subjective and Objective Measures of Adherence to Oral Antipsychotic Medications
Psychiatr Serv, September 1, 2007; 58(9): 1187 - 1192.
[Abstract] [Full Text] [PDF]

Home page
 Psychiatr. Serv.Home page
T. M. Kashner, A. J. Rush, M. L. Crismon, M. Toprac, T. J. Carmody, A. L. Miller, M. H. Trivedi, A. Wicker, and T. Suppes
An Empirical Analysis of Cost Outcomes of the Texas Medication Algorithm Project
Psychiatr Serv, May 1, 2006; 57(5): 648 - 659.
[Abstract] [Full Text] [PDF]

Home page
 Schizophr BullHome page
L. B Dunn, P. J Candilis, and L. W. Roberts
Emerging Empirical Evidence on the Ethics of Schizophrenia Research
Schizophr Bull, January 1, 2006; 32(1): 47 - 68.
[Abstract] [Full Text] [PDF]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.