Skip Navigation


Schizophrenia Bulletin Advance Access originally published online on February 16, 2005
Schizophrenia Bulletin 2005 31(1):139-153; doi:10.1093/schbul/sbi005
This Article
Right arrow Full Text Freely available
Right arrow FREE Full Text (PDF) Freely available
Right arrow All Versions of this Article:
31/1/139    most recent
sbi005v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Google Scholar
Right arrow Articles by Lubow, R E
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Lubow, R E
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

Schizophrenia Bulletin vol. 31 no. 1 © The Author 2005. Published by Oxford University Press on behalf of the Maryland Psychiatric Research Center. All rights reserved. For Permissions, please email: journals.permissions@oupjournals.org

Construct Validity of the Animal Latent Inhibition Model of Selective Attention Deficits in Schizophrenia

R E Lubow, Ph.D.
Professor, Department of Psychology, Tel Aviv University, Tel Aviv, Israel

Send reprint requests to Dr. R. E. Lubow, Department of Psychology, Tel Aviv University, Ramat Aviv 69978, Israel; e-mail: lubow{at}freud.tau.ac.il.

Latent inhibition (LI) is demonstrated when a previously unattended/inconsequential stimulus is less effective in a new learning situation than a novel stimulus. In rats and humans, LI is reduced by dopamine agonists and increased by dopamine antagonists. In addition, LI is attenuated in actively psychotic schizophrenia patients, thus conferring strong predictive validity to the animal LI preparation for schizophrenia. However, the validity of the attentional construct in the LI model of schizophrenia dysfunction depends on confirming two assumptions: that animal and human LI share a common process, and that the process is related to selective attention. Evidence to support both assumptions is presented, followed by a description of a conditioned attention theory that emphasizes the role of initial levels of attention elicited by repeated relevant and irrelevant stimuli, and the differences between these levels in schizophrenia and normal groups.

Keywords: Schizophrenia / schizotypal / dopamine / latent inhibition / attention / construct validity / predictive validity / animal model


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 Schizophr BullHome page
U. Meyer, J. Feldon, and B. K. Yee
A Review of the Fetal Brain Cytokine Imbalance Hypothesis of Schizophrenia
Schizophr Bull, September 1, 2009; 35(5): 959 - 972.
[Abstract] [Full Text] [PDF]

Home page
 Schizophr BullHome page
U. Meyer, E. Spoerri, B. K. Yee, M. J. Schwarz, and J. Feldon
Evaluating Early Preventive Antipsychotic and Antidepressant Drug Treatment in an Infection-Based Neurodevelopmental Mouse Model of Schizophrenia
Schizophr Bull, October 8, 2008; (2008) sbn131v1.
[Abstract] [Full Text] [PDF]

Home page
 Schizophr BullHome page
S. M. Silverstein
Measuring Specific, Rather than Generalized, Cognitive Deficits and Maximizing Between-Group Effect Size in Studies of Cognition and Cognitive Change
Schizophr Bull, July 1, 2008; 34(4): 645 - 655.
[Abstract] [Full Text] [PDF]

Home page
 Schizophr BullHome page
J. J Hagan and D. N C Jones
Predicting Drug Efficacy for Cognitive Deficits in Schizophrenia
Schizophr Bull, October 1, 2005; 31(4): 830 - 853.
[Abstract] [Full Text] [PDF]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.