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Schizophrenia Bulletin Advance Access originally published online on August 17, 2005
Schizophrenia Bulletin 2005 31(4):854-864; doi:10.1093/schbul/sbi044
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© The Author 2005. Published by Oxford University Press on behalf of the Maryland Psychiatric Research Center. All rights reserved. For permissions, please email: journals.permissions@oupjournals.org.

Synthesizing Schizophrenia: A Bottom-Up, Symptomatic Approach

Trevor W Robbins
Department of Experimental Psychology, University of Cambridge, Downing St., Cambridge CB2 3EB, UK

To whom correspondence should be addressed; tel: 44-1223-333551, fax: 44-1223-333564, e-mail: twr2{at}cam.ac.uk.

The cognitive deficits in schizophrenia are discussed in terms of the other symptoms of the disorder, as well as according to a translational approach that involves using similar or analogous tests for humans and experimental animals. This approach, it is argued, will enable the testing of novel drugs and the development of adequate etiological models of schizophrenia.

Keywords: cognition / memory / attention / prefrontal cortex / psychosis / dopamine


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