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Schizophrenia Bulletin Advance Access originally published online on November 30, 2005
Schizophrenia Bulletin 2006 32(2):332-340; doi:10.1093/schbul/sbj030
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© The Author 2005. Published by Oxford University Press on behalf of the Maryland Psychiatric Research Center. All rights reserved. For permissions, please email: journals.permissions@oxfordjournals.org.

Hippocampal and Parahippocampal Volumes in Schizophrenia: A Structural MRI Study

Kang Sim1,2,5,, Iain DeWitt3, Tali Ditman3, Martin Zalesak3, Ian Greenhouse2, Donald Goff4, Anthony P Weiss3,4, and Stephan Heckers2–4,
2 Schizophrenia and Bipolar Disorders Unit, McLean Hospital, Belmont, MA
3 Athinoula A. Martinos Center for Biomedical Imaging, Charlestown, MA
4 Department of Psychiatry, Massachusetts General Hospital, Boston, MA
5 Institute of Mental Health/Woodbridge Hospital, Singapore

1To whom correspondence should be addressed; Schizophrenia and Bipolar Disorders Program, McLean Hospital/Harvard Medical School, Mill Street, Belmont, MA, 02478, tel: 617-855-2961, fax: 617-855-2895; e-mail: ksim{at}mclean.harvard.edu, kang_sim{at}imh.com.sg.

Smaller medial temporal lobe volume is a frequent finding in studies of patients with schizophrenia, but the relative contributions of the hippocampus and three surrounding cortical regions (entorhinal cortex, perirhinal cortex, and parahippocampal cortex) are poorly understood. We tested the hypothesis that the volumes of medial temporal lobe regions are selectively changed in schizophrenia. We studied 19 male patients with schizophrenia and 19 age-matched male control subjects. Hippocampal and cortical volumes were estimated using a three-dimensional morphometric protocol for the analysis of high-resolution structural magnetic resonance images, and repeated measures ANOVA was used to test for region-specific differences. Patients had smaller overall medial temporal lobe volumes compared to controls. The volume difference was not specific for either region or hemisphere. The finding of smaller medial temporal lobe volumes in the absence of regional specificity has important implications for studying the functional role of the hippocampus and surrounding cortical regions in schizophrenia.

Keywords: medial temporal lobe / entorhinal / perirhinal / parahippocampal / region / functional


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