Skip Navigation


Schizophrenia Bulletin Advance Access originally published online on October 27, 2005
Schizophrenia Bulletin 2006 32(3):556-561; doi:10.1093/schbul/sbj020
This Article
Right arrow Full Text Freely available
Right arrow FREE Full Text (PDF) Freely available
Right arrow All Versions of this Article:
32/3/556    most recent
sbj020v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Google Scholar
Right arrow Articles by Jin, Y.
Right arrow Articles by Bunney, W. E.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Jin, Y.
Right arrow Articles by Bunney, W. E., Jr.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

© The Author 2005. Published by Oxford University Press on behalf of the Maryland Psychiatric Research Center. All rights reserved. For permissions, please email: journals.permissions@oxfordjournals.org.

Therapeutic Effects of Individualized Alpha Frequency Transcranial Magnetic Stimulation ({alpha}TMS) on the Negative Symptoms of Schizophrenia

Yi Jin1,2, Steven G. Potkin2, Aaron S. Kemp2, Steven T. Huerta2, Gustavo Alva2, Trung Minh Thai2, Danilo Carreon2 and William E. Bunney, Jr.2
2 Department of Psychiatry and Human Behavior, University of California, Irvine, School of Medicine

1To whom correspondence should be addressed; e-mail: yjin{at}uci.edu.

Previous research in clinical electroencephalography (EEG) has demonstrated that reduction of alpha frequency (8–13 Hz) EEG activity may have particular relevance to the negative symptoms of schizophrenia. Repetitive Transcranial Magnetic Stimulation (rTMS) was utilized to investigate this relationship by assessing the therapeutic effects of stimulation set individually at each subject's peak alpha frequency ({alpha}TMS). Twenty-seven subjects, with predominantly negative symptom schizophrenia, received 2 weeks of daily treatment with either {alpha}TMS, 3 Hz, 20 Hz, or sham stimulation bilaterally over the dorsolateral prefrontal cortex. Individualized {alpha}TMS demonstrated a significantly larger (F 3,33 = 4.7, p = .007) therapeutic effect (29.6% reduction in negative symptoms) than the other 3 conditions (< 9%). Furthermore, these clinical improvements were found to be highly correlated (r = 0.86, p = .001) with increases (34%) in frontal alpha amplitude following {alpha}TMS. These results affirm that the resonant features of alpha frequency EEG play an important role in the pathophysiology of schizophrenia and merit further investigation as a particularly efficacious frequency for rTMS treatments.

Keywords: alpha rhythm / {alpha}TMS / schizophrenia / EEG / transcranial magnetic stimulation


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?




Disclaimer:
Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.