Skip Navigation


Schizophrenia Bulletin Advance Access originally published online on August 16, 2006
Schizophrenia Bulletin 2006 32(4):609-613; doi:10.1093/schbul/sbl032
This Article
Right arrow Full Text Freely available
Right arrow FREE Full Text (PDF) Freely available
Right arrow All Versions of this Article:
32/4/609    most recent
sbl032v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Google Scholar
Right arrow Articles by McGlashan, T.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by McGlashan, T.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

© The Author 2006. Published by Oxford University Press on behalf of the Maryland Psychiatric Research Center. All rights reserved. For permissions, please email: journals.permissions@oxfordjournals.org.

Schizophrenia in Translation: Is Active Psychosis Neurotoxic?

TH McGlashan1
1To whom correspondence should be addressed; e-mail: thomas.mcglashan{at}yale.edu.

Positive symptoms of psychosis disrupt mentation. Do they also engineer brain cell death and deterioration? This hypothesis is currently popular as an explanation of the duration of untreated psychosis effect in early schizophrenia. The clinical and neurobiological evidence for its validity is visited and found wanting. Synaptic plasticity, not neurotoxicity, appears to be the mediating process.

Keywords: deterioration / duration of untreated psychosis (DUP) / neurodegeneration / synaptic connectivity and plasticity


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 Schizophr BullHome page
P. DeRosse, T. Lencz, K. E. Burdick, S. G. Siris, J. M. Kane, and A. K. Malhotra
The Genetics of Symptom-Based Phenotypes: Toward a Molecular Classification of Schizophrenia
Schizophr Bull, July 15, 2008; (2008) sbn076v1.
[Abstract] [Full Text] [PDF]

Home page
 Arch Gen PsychiatryHome page
I. Melle, T. K. Larsen, U. Haahr, S. Friis, J. O. Johannesen, S. Opjordsmoen, B. R. Rund, E. Simonsen, P. Vaglum, and T. McGlashan
Prevention of Negative Symptom Psychopathologies in First-Episode Schizophrenia: Two-Year Effects of Reducing the Duration of Untreated Psychosis
Arch Gen Psychiatry, June 1, 2008; 65(6): 634 - 640.
[Abstract] [Full Text] [PDF]

Home page
 Schizophr BullHome page
S. Reig, C. Moreno, D. Moreno, M. Burdalo, J. Janssen, M. Parellada, A. Zabala, M. Desco, and C. Arango
Progression of Brain Volume Changes in Adolescent-Onset Psychosis
Schizophr Bull, January 24, 2008; (2008) sbm160v1.
[Abstract] [Full Text] [PDF]

Home page
 Br. J. PsychiatryHome page
S. P. Singh
Outcome measures in early psychosis: Relevance of duration of untreated psychosis
The British Journal of Psychiatry, August 1, 2007; 191(50): s58 - s63.
[Abstract] [Full Text] [PDF]

Home page
 J Am Acad Psychiatry LawHome page
S. K. Erickson, J. R. Ciccone, S. B. Schwarzkopf, J. S. Lamberti, and M. J. Vitacco
Legal Fallacies of Antipsychotic Drugs
J Am Acad Psychiatry Law, June 1, 2007; 35(2): 235 - 246.
[Abstract] [Full Text] [PDF]


Disclaimer:
Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.