Schizophrenia Bulletin Advance Access originally published online on January 25, 2007
Schizophrenia Bulletin 2007 33(3):665-672; doi:10.1093/schbul/sbl075
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North American Prodrome Longitudinal Study: A Collaborative Multisite Approach to Prodromal Schizophrenia Research
2 Department of Psychiatry, University of Toronto, Toronto
3 Department of Psychiatry, University of California, San Diego
4 Departments of Psychology and Psychiatry and Biobehavioral Sciences, University of California Los Angeles
5 Recognition and Prevention Program, Department of Psychiatry Research, the Zucker Hillside Hospital, North-Shore Long Island Health System, Glen Oaks, NY
6 Department of Psychiatry, Albert Einstein College of Medicine, Bronx, NY
7 Yale University, School of Medicine
8 Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, NC
9 Harvard Medical School, Departments of Psychiatry at Massachusetts Mental Health Center Public Psychiatry Division, Beth Israel Deaconess Medical Center, and Massachusetts General Hospital, Boston, MA
10 Center for Behavioral Genomics, Department of Psychiatry, University of California, San Diego, CA
11 Harvard Institute of Psychiatric Epidemiology and Genetics, Boston, MA
12 Department of Psychology, Emory University, Atlanta, GA
13 Division of Adult Translational Research and Treatment Development, National Institute of Mental Health
1 To whom correspondence should be addressed; Centre for Addiction and Mental Health, 250 College Street, Toronto, Ontario, M5T 1R8, Canada; tel: 416-535-8501, fax: 416-979-6936, e-mail: jean_addington{at}camh.net.
This article presents the rationale, design, and preliminary findings of the North American Prodrome Longitudinal Study (NAPLS), a collaborative, multisite investigation into the earliest phase of psychotic illness. We describe how 8 independently conceived research projects were integrated methodologically, how diagnostic reliability was achieved across sites on the Structured Interview for Prodromal Syndromes, and how baseline and follow-up data were aggregated for 888 at risk and comparison subjects. Data are presented describing the demographic, academic/work, and diagnostic characteristics of 3 relevant subgroups: persons at heightened clinical risk for psychosis, help-seeking comparison subjects, and nonpsychiatric controls. The NAPLS data set will be used to explore a series of questions related to prodromal psychosis, including the descriptive phenomenology of currently accepted diagnostic criteria, conversion rates over a 30-month period, predictors of psychosis onset and functional disability, and the impact of early treatment on the course of prodromal symptoms.
Keywords: psychosis / prodrome / schizophrenia / consortium / early detection / prevention / NAPLS
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