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Schizophrenia Bulletin Advance Access originally published online on January 11, 2007
Schizophrenia Bulletin 2007 33(3):757-760; doi:10.1093/schbul/sbl074
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© The Author 2007. Published by Oxford University Press on behalf of the Maryland Psychiatric Research Center. All rights reserved. For permissions, please email: journals.permissions@oxfordjournals.org.

Effects of Toxoplasma on Human Behavior

Jaroslav Flegr1,2
2 Department of Parasitology, Faculty of Science, Charles University, Vinicná 7, CZ-128 44 Praha 2, Czech Republic

1 To whom correspondence should be addressed; tel: +420 221951821, fax: +420 224919704, e-mail: flegr{at}cesnet.cz.

Although latent infection with Toxoplasma gondii is among the most prevalent of human infections, it has been generally assumed that, except for congenital transmission, it is asymptomatic. The demonstration that latent Toxoplasma infections can alter behavior in rodents has led to a reconsideration of this assumption. When infected human adults were compared with uninfected adults on personality questionnaires or on a panel of behavioral tests, several differences were found. Other studies have demonstrated reduced psychomotor performance in affected individuals. Possible mechanisms by which T. gondii may affect human behavior include its effect on dopamine and on testosterone.

Keywords: personality test / reaction time / dopamine / testosterone


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