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Schizophrenia Bulletin Advance Access originally published online on June 16, 2007
Schizophrenia Bulletin 2007 33(4):932-936; doi:10.1093/schbul/sbm064
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Published by Oxford University Press 2007.

Searching for Unique Endophenotypes for Schizophrenia and Bipolar Disorder Within Neural Circuits and Their Molecular Regulatory Mechanisms

Francine M. Benes1,2,3
2 Program in Structural and Molecular Neuroscience, McLean Hospital, 115 Mill Street, Belmont, MA 02478
3 Program in Neuroscience and Department of Psychiatry, Harvard Medical School, Boston, MA

1 To whom correspondence should be addressed; tel: 617-855-2401, fax: 617-855-3199, e-mail: fbenes{at}mclean.harvard.edu.

The endophenotype is a construct that has utility for the study of postmortem brains from patients with psychotic disorders. By identifying networks of genes that show changes in expression within specific neuronal populations implicated in the pathophysiology of schizophrenia and bipolar disorder, it may be possible to move toward understanding these disorders at the cellular and molecular levels. The ultimate goal is to characterize their respective underlying genotypes.

Keywords: apoptosis / L-type calcium channel / antioxidation genes / cell viability / gene expression profiling


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