Skip Navigation


Schizophrenia Bulletin Advance Access originally published online on August 21, 2007
Schizophrenia Bulletin 2007 33(6):1270-1273; doi:10.1093/schbul/sbm093
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
33/6/1270    most recent
sbm093v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Google Scholar
Right arrow Articles by Perrin, M. C.
Right arrow Articles by Malaspina, D.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Perrin, M. C.
Right arrow Articles by Malaspina, D.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

© The Author 2007. Published by Oxford University Press on behalf of the Maryland Psychiatric Research Center. All rights reserved. For permissions, please email: journals.permissions@oxfordjournals.org.

Aberrant Epigenetic Regulation Could Explain the Relationship of Paternal Age to Schizophrenia

Mary C. Perrin2, Alan S. Brown3,4 and Dolores Malaspina1,2
2 Department of Psychiatry, School of Medicine, New York University, New York, NY
3 New York State Psychiatric Institute, New York, NY
4 Department of Psychiatry, Columbia University, New York, NY

1 To whom correspondence should be addressed; tel: 212-263-6214, fax: 212-263-5717, e-mail: Dolores.Malaspina{at}NYUMC.ORG.

The causal mechanism underlying the well-established relation between advancing paternal age and schizophrenia is hypothesized to involve mutational errors during spermatogenesis that occur with increasing frequency as males age. Point mutations are well known to increase with advancing paternal age while other errors such as altered copy number in repeat DNA and chromosome breakage have in some cases also been associated with advancing paternal age. Dysregulation of epigenetic processes may also be an important mechanism underlying the association between paternal age and schizophrenia. Evidence suggests that advancing age as well as environmental exposures alter epigenetic regulation. Errors in epigenetic processes, such as parental imprinting can have serious effects on the offspring both pre- and postnatally and into adulthood. This article will discuss parental imprinting on the autosomal and X chromosomes and the alterations in epigenetic regulation that may lead to such errors.

Keywords: methylation / imprinting / X-chromosome inactivation / schizophrenia


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 Schizophr BullHome page
D. Collip, I. Myin-Germeys, and J. Van Os
Does the Concept of "Sensitization" Provide a Plausible Mechanism for the Putative Link Between the Environment and Schizophrenia?
Schizophr Bull, March 1, 2008; 34(2): 220 - 225.
[Abstract] [Full Text] [PDF]


Disclaimer:
Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.