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Schizophrenia Bulletin Advance Access originally published online on December 16, 2006
Schizophrenia Bulletin 2007 33(6):1307-1311; doi:10.1093/schbul/sbl069
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© The Author 2006. Published by Oxford University Press on behalf of the Maryland Psychiatric Research Center. All rights reserved. For permissions, please email: journals.permissions@oxfordjournals.org.

Reduced Frontal Asymmetry of Delta Waves During All-Night Sleep in Schizophrenia

Masanori Sekimoto1,2, Masaaki Kato2, Tsuyoshi Watanabe2, Naofumi Kajimura2 and Kiyohisa Takahashi2
2 National Center Hospital for Mental, Nervous and Muscular Disorders, National Center of Neurology and Psychiatry, Tokyo, Japan

1 To whom correspondence should be addressed; Department of Psychiatry, Medical Division, Fuchu Prison, 4-10, Harumi, Fuchu, Tokyo 183-8523, Japan, tel: +81-42-362-3101, fax: +81-42-340-7416, e-mail: rinosama{at}amber.plala.or.jp.

Delta wave deficits during sleep have been observed in patients with schizophrenia. Decreased slow-wave sleep is reported to be associated with negative symptoms. Frontal lobe dysfunction is also believed to underlie negative symptoms of schizophrenia. This study was designed to identify functional abnormalities in schizophrenia manifested on patients' electroencephalograms. Polysomnograph examinations were performed in 12 healthy male volunteers and 11 male outpatients with schizophrenia. We investigated the laterality of frontal cortical delta waves in patients with schizophrenia and in healthy control subjects. Laterality of frontal cortex delta wave counts during all-night sleep was investigated by computer analysis. Total delta wave counts were lower in patients with schizophrenia than in control subjects. Control subjects showed significantly higher delta wave counts in the right frontal cortex than in the left. This asymmetry was not observed in patients with schizophrenia. These findings suggest that reduced right frontal delta wave dominance is involved in the pathophysiology of schizophrenia.

Keywords: schizophrenia / polysomnogram / negative symptom / laterality / pathophysiology / period-amplitude analysis


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