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Schizophrenia Bulletin Advance Access originally published online on May 22, 2008
Schizophrenia Bulletin 2008 34(4):791-797; doi:10.1093/schbul/sbn050
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© The Author 2008. Published by Oxford University Press on behalf of the Maryland Psychiatric Research Center. All rights reserved. For permissions, please email: journals.permissions@oxfordjournals.org.

Approaches for Unraveling the Joint Genetic Determinants of Schizophrenia and Bipolar Disorder

Ping-I Lin1,2,3 and Braxton D. Mitchell3
2 Division of Endocrinology, Department of Medicine, University of Maryland School of Medicine, Baltimore, MD
3 Maryland Psychiatric Research Center, Department of Psychiatry, University of Maryland School of Medicine, Catonsville, MD

1 To whom correspondence should be addressed; 685 W Baltimore Street MSTF 314D, Baltimore, MD 21201; tel: 410-706-5763, fax: 410-706-6430, e-mail: pingi.lin{at}gmail.com.

Since Emil Kraepelin proposed in 1919 that dementia praecox (schizophrenia) be differentiated from manic depression (bipolar disorder), the concept of nosological dichotomy has greatly influenced the diagnosis, treatment, and research of pathogenesis of these 2 disorders. However, this concept has recently been challenged by increasing evidence showing biological overlap between schizophrenia and bipolar disorder. This article reviews some of the previous evidence for phenomenological and molecular overlaps between these 2 disorders. We then discuss approaches for examining shared etiological mechanisms with a concentration on genetic factors. We have put a particular emphasis on incorporating the concept of endophenotypes in research of shared genetic liability for these 2 disorders.

Keywords: schizophrenia / bipolar disorder / genes / endophenotype


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