Skip Navigation


Schizophrenia Bulletin Advance Access originally published online on August 14, 2008
Schizophrenia Bulletin 2008 34(6):1122-1129; doi:10.1093/schbul/sbn105
This Article
Right arrow Full Text Freely available
Right arrow FREE Full Text (PDF) Freely available
Right arrow All Versions of this Article:
34/6/1122    most recent
sbn105v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Google Scholar
Right arrow Articles by Oh, G.
Right arrow Articles by Petronis, A.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Oh, G.
Right arrow Articles by Petronis, A.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

© The Author 2008. Published by Oxford University Press on behalf of the Maryland Psychiatric Research Center. All rights reserved. For permissions, please email: journals.permissions@oxfordjournals.org.

Environmental Studies of Schizophrenia Through the Prism of Epigenetics

Gabriel Oh2 and Arturas Petronis1,2
2 The Krembil Family Epigenetics Laboratory, Centre for Addiction and Mental Health, University of Toronto, 250 College Street, Toronto, Ontario M5T 1R8, Canada

1 To whom correspondence should be addressed; tel: 416-535-8501 ext 4880, fax: 416-979-4666, e-mail: arturas_petronis{at}camh.net.

Traditionally, etiological research of schizophrenia has been focused on elucidating predisposing genes and environmental risk factors. While numerous putative environmental hazards have been suggested, inconsistencies and methodological limitations of epidemiological studies have made it difficult to identify even a single exogenous cause of schizophrenia. Furthermore, there is increasing evidence that environmental risk factors may not play as much of a significant role in schizophrenia as previously suspected. In this article, we argue that molecular epigenetic studies can overcome the complexities of traditional epidemiological studies and may become a productive line of research in understanding the nongenetic mechanisms of schizophrenia.

Keywords: schizophrenia / epidemiology / environment / epigenetics / DNA methylation


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 Schizophr BullHome page
B. P. F. Rutten and J. Mill
Epigenetic Mediation of Environmental Influences in Major Psychotic Disorders
Schizophr Bull, November 1, 2009; 35(6): 1045 - 1056.
[Abstract] [Full Text] [PDF]

Home page
 Biol. Reprod.Home page
P. C. Haycock
Fetal Alcohol Spectrum Disorders: The Epigenetic Perspective
Biol Reprod, October 1, 2009; 81(4): 607 - 617.
[Abstract] [Full Text] [PDF]

Home page
 Schizophr BullHome page
J. J. McGrath and L. J. Richards
Why Schizophrenia Epidemiology Needs Neurobiology--and Vice Versa
Schizophr Bull, May 1, 2009; 35(3): 577 - 581.
[Abstract] [Full Text] [PDF]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.