Schizophrenia Bulletin Advance Access originally published online on November 20, 2008
Schizophrenia Bulletin 2009 35(1):109-114; doi:10.1093/schbul/sbn163
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Selecting Paradigms From Cognitive Neuroscience for Translation into Use in Clinical Trials: Proceedings of the Third CNTRICS Meeting
2 Washington Universityin St. Louis, MO
3 University of California, Davis, CA
4 Yale University, New Haven, CT
5 Maryland Psychiatric Research Center, Baltimore MD
6 Princeton University, Princeton NJ
7 University of California at San Diego, CA
8 Semel Institute at UCLA and VA Greater Los Angeles Healthcare System, Los ANgeles, CA
9 University of California at Los Angeles, CA
10 University of Cambridge, Cambridge, England
11 University of Medicine and Dentistry of New Jersey, Rutgers, NJ
12 Columbia University, New York, NY
13 University of New Mexico, Albequerque NM
14 Institute of Psychiatry, King's College London, England
15 National Institute of Mental Health, Bethesda MD
1 To whom correspondence should be addressed; tel: 314-935-8729, fax: 314-935-8790, e-mail: dbarch{at}artsci.wustl.edu.
This overview describes the goals and objectives of the third conference conducted as part of the Cognitive Neuroscience Treatment Research to Improve Cognition in Schizophrenia (CNTRICS) initiative. This third conference was focused on selecting specific paradigms from cognitive neuroscience that measured the constructs identified in the first CNTRICS meeting, with the goal of facilitating the translation of these paradigms into use in clinical trials contexts. To identify such paradigms, we had an open nomination process in which the field was asked to nominate potentially relevant paradigms and to provide information on several domains relevant to selecting the most promising tasks for each construct (eg, construct validity, neural bases, psychometrics, availability of animal models). Our goal was to identify 1–2 promising tasks for each of the 11 constructs identified at the first CNTRICS meeting. In this overview article, we describe the on-line survey used to generate nominations for promising tasks, the criteria that were used to select the tasks, the rationale behind the criteria, and the ways in which breakout groups worked together to identify the most promising tasks from among those nominated. This article serves as an introduction to the set of 6 articles included in this special issue that provide information about the specific tasks discussed and selected for the constructs from each of 6 broad domains (working memory, executive control, attention, long-term memory, perception, and social cognition).
Keywords: cognition / treatment / schizophrenia