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Schizophrenia Bulletin Advance Access originally published online on November 5, 2008
Schizophrenia Bulletin 2009 35(1):136-152; doi:10.1093/schbul/sbn153
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© The Author 2008. Published by Oxford University Press on behalf of the Maryland Psychiatric Research Center. All rights reserved. For permissions, please email: journals.permissions@oxfordjournals.org.

CNTRICS Final Task Selection: Working Memory

Deanna M. Barch1,2, Marc G. Berman3, Randy Engle4, Jessica Hurdelbrink Jones6, John Jonides3, Angus MacDonald, III6, Derek Evan Nee3, Thomas S. Redick4 and Scott R. Sponheim5,6
2 Departments of Psychology, Psychiatry, and Radiology, Washington University, St Louis, Mo
3 Department of Psychology, University of Michigan
4 School of Psychology, Georgia Institute of Technology
5 Veterans Affairs Medical Center in Minneapolis
6 Department of Psychology, University of Minnesota

1 To whom correspondence should be addressed; Department of Psychology, Washington University, St Louis, MO, 63130; tel: 314-935-8729, fax: 314-935-8790, e-mail: dbarch{at}artsci.wustl.edu.

The third meeting of the Cognitive Neuroscience Treatment Research to Improve Cognition in Schizophrenia (CNTRICS) was focused on selecting promising measures for each of the cognitive constructs selected in the first CNTRICS meeting. In the domain of working memory, the 2 constructs of interest were goal maintenance and interference control. CNTRICS received 3 task nominations for each of these constructs, and the breakout group for working memory evaluated the degree to which each of these tasks met prespecified criteria. For goal maintenance, the breakout group for working memory recommended the AX-Continuous Performance Task/Dot Pattern Expectancy task for translation for use in clinical trial contexts in schizophrenia research. For interference control, the breakout group recommended the recent probes and operation/symmetry span tasks for translation for use in clinical trials. This article describes the ways in which each of these tasks met the criteria used by the breakout group to recommend tasks for further development.

Keywords: inference control / goal maintenance / schizophrenia


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