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Schizophrenia Bulletin Advance Access originally published online on November 20, 2008
Schizophrenia Bulletin 2009 35(1):163-181; doi:10.1093/schbul/sbn156
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© The Author 2008. Published by Oxford University Press on behalf of the Maryland Psychiatric Research Center. All rights reserved. For permissions, please email: journals.permissions@oxfordjournals.org.

Perception Measurement in Clinical Trials of Schizophrenia: Promising Paradigms From CNTRICS

Michael F. Green1,2, Pamela D. Butler35, Yue Chen6, Mark A. Geyer7, Steven Silverstein8, Jonathan K. Wynn2, Jong H. Yoon9 and Vance Zemon10
2 Semel Institute at UCLA and VA Greater Los Angeles Healthcare System, Los Angeles, CA
3 Nathan Kline Institute for Psychiatric Research, Orangeburg, NY
4 Department of Psychiatry, New York University School of Medicine, New York, NY
5 Cognitive Neuroscience Program, University of New York, New York, NY
6 McLean Hospital, Department of Psychiatry, Harvard Medical School, Belmont, MA
7 Department of Psychiatry, University of California San Diego, La Jolla, CA 92093-0804
8 University Behavioral HealthCare and Robert Wood Johnson Medical School, Piscataway, NJ
9 Department of Psychiatry, University of California, Davis, CA
10 Ferkauf Graduate School of Psychology, Yeshiva University, Bronx, NY

1 To whom correspondence should be addressed; tel: (310) 794-1993; fax: (310) 825-6626, e-mail: mgreen{at}ucla.edu.

The third meeting of the Cognitive Neuroscience Treatment Research to Improve Cognition in Schizophrenia (CNTRICS) focused on selecting promising measures for each of the cognitive constructs selected in the first CNTRICS meeting. In the domain of perception, the 2 constructs of interest were gain control and visual integration. CNTRICS received 5 task nominations for gain control and three task nominations for visual integration. The breakout group for perception evaluated the degree to which each of these tasks met prespecified criteria. For gain control, the breakout group for perception believed that 2 of the tasks (prepulse inhibition of startle and mismatch negativity) were already mature and in the process of being incorporated into multisite clinical trials. However, the breakout group recommended that steady-state visual-evoked potentials be combined with contrast sensitivity to magnocellular vs parvocellular biased stimuli and that this combined task and the contrast-contrast effect task be recommended for translation for use in clinical trial contexts in schizophrenia research. For visual integration, the breakout group recommended the Contour Integration and Coherent Motion tasks for translation for use in clinical trials. This manuscript describes the ways in which each of these tasks met the criteria used by the breakout group to evaluate and recommend tasks for further development.

Keywords: perception / CNTRICS / sensory processes

Coauthors had equivalent input and are listed in alphabetical order.


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