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Schizophrenia Bulletin Advance Access originally published online on March 27, 2009
Schizophrenia Bulletin 2009 35(3):493-508; doi:10.1093/schbul/sbp017
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© The Author 2009. Published by Oxford University Press on behalf of the Maryland Psychiatric Research Center. All rights reserved. For permissions, please email: journals.permissions@oxfordjournals.org.

What We Know: Findings That Every Theory of Schizophrenia Should Explain

Angus W. MacDonald13 and S. Charles Schulz3
2 Departments of Psychology and Psychiatry
3 Department of Psychiatry, University of Minnesota, Minneapolis, MN

1 To whom correspondence should be addressed; Department of Psychology, University of Minnesota, N426 Elliott Hall, 75 E. River Rd., Minneapolis, MN 55455; tel: (612) 624-3813, fax: (612) 625-6668, e-mail: angus{at}umn.edu.

The article summarizes the process used to distill schizophrenia science into 22 facts. These facts consist of 6 basic facts, 3 etiological facts, 6 pharmacological and treatment facts, 5 pathology facts, and 2 behavioral facts that were critically reviewed by the scholarly community through a special initiative in cooperation with the Schizophrenia Research Forum. A subset of 10 of these facts was selected to form a common set of findings to be explained from the different theoretical perspectives included in this special section of Schizophrenia Bulletin. The rationale for this exercise is to distinguish more precisely the areas of agreement and disagreement between theories of schizophrenia and to highlight where more thought and data can make the greatest impact for understanding this disease.

Keywords: Schizophrenia / review / meta-analysis / theory


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