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Schizophrenia Bulletin Advance Access published online on January 31, 2008
Schizophrenia Bulletin, doi:10.1093/schbul/sbn002
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© The Author 2008. Published by Oxford University Press on behalf of the Maryland Psychiatric Research Center. All rights reserved. For permissions, please email: journals.permissions@oxfordjournals.org.

Life Events and High-Trait Reactivity Together Predict Psychotic Symptom Increases in Schizophrenia

Nancy M. Docherty1, Annie St-Hilaire, Jennifer M. Aakre and James P. Seghers
Department of Psychology, Kent State University, PO Box 5190, Kent, OH 44242

1 To whom correspondence should be addressed; tel: 330-672-7670, fax: 672-3786, e-mail: ndochert{at}kent.edu.

Psychotic symptoms are exacerbated by stressful life events in schizophrenia patients as a group. Some individuals appear to be more vulnerable than others in this regard. This study tested whether schizophrenia patients are highly emotionally reactive compared with controls and whether the level of trait emotional reactivity in patients influences the degree to which they respond to life stressors with exacerbations of psychosis. Schizophrenic outpatients and nonpsychiatric controls were assessed for levels of trait emotional reactivity, arousability, and trait anxiety. Severity of symptoms was also rated in the patients. Patients were then followed up 9 months later, assessed for independent stressful life events occurring during the month before the follow-up session, and reassessed for symptom levels. The patients scored higher than the control subjects on all 3 measures of reactivity at the initial assessment. At follow-up, the occurrence of potentially stressful life events predicted increases in psychotic symptoms in patients, and there was a significant interaction between level of initial trait reactivity and the occurrence of life events in the prediction of these increases. High-trait–reactive patients showed increases in psychotic symptoms in response to life stressors, whereas low-trait–reactive patients did not. These findings support the idea that patients as a group have higher than normal levels of trait reactivity and also that patients with very high levels of trait reactivity are at elevated risk of psychotic relapse under stress. Such patients might benefit particularly from interventions designed to assist them in coping with potentially stressful life events and circumstances.

Keywords: Stress / life events / trait reactivity / relapse / delusions


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