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Schizophrenia Bulletin Advance Access published online on August 25, 2009
Schizophrenia Bulletin, doi:10.1093/schbul/sbp062
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© The Author 2009. Published by Oxford University Press on behalf of the Maryland Psychiatric Research Center. All rights reserved. For permissions, please email: journals.permissions@oxfordjournals.org.

Cognitive Efficacy of Quetiapine and Olanzapine in Early-Onset First-Episode Psychosis

Olalla Robles2, Arantzazu Zabala2,3, Igor Bombín4,5, Mara Parellada2, Dolores Moreno2, Ana Ruiz-Sancho2 and Celso Arango1,2
2 Adolescent Unit, Psychiatry Department, Hospital General Universitario Gregorio Marañón, Centro de Investigación Biomédica en Red de Salud Mental, CIBERSAM, C/Ibiza 43, 28009 Madrid, Spain
3 Department of Neuroscience. School of Medicine and Odontology, University of the Basque Country (UPV)
4 Reintegra Foundation and Reintegra: Neurological Rehab Center, Oviedo, Spain
5 Universidad de Oviedo, Centro de Investigación Biomédica en Red de Salud Mental, CIBERSAM, Oviedo, Spain

1 To whom correspondence should be addressed; tel: +34-914265006, fax: +34-914265004, e-mail: carango{at}hggm.es.

The primary purpose of this study was to compare changes in cognition in early-onset psychosis after 6-months treatment with quetiapine or olanzapine. This is a randomized, single-blind, 6-month study in 50 adolescents with a diagnosis of early-onset psychosis. Patients were randomized to quetiapine (n = 24) or olanzapine (n = 26). A thorough neuropsychological battery was administered at baseline and after 6-month treatment. Out of the total sample included in the study, 32 patients completed at least 6-months treatment with the assigned medication (quetiapine, n = 16; olanzapine, n = 16). No changes were observed in cognitive performance after 6-month treatment with quetiapine or olanzapine. Although some trends toward cognitive improvement were observed for the olanzapine group after 6-month treatment, neither group showed statistically significant gains. Furthermore, there was no evidence of any differential efficacy of olanzapine or quetiapine on cognitive improvement in this sample of adolescents with psychosis.

Keywords: clinical trial / antipsychotics / childhood-onset psychosis


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