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Schizophrenia Bulletin Advance Access published online on June 23, 2009
Schizophrenia Bulletin, doi:10.1093/schbul/sbp063
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© The Author 2009. Published by Oxford University Press on behalf of the Maryland Psychiatric Research Center. All rights reserved. For permissions, please email: journals.permissions@oxfordjournals.org.

The Relationship Among Neuregulin 1–Stimulated Phosphorylation of AKT, Psychosis Proneness, and Habituation of Arousal in Nonclinical Individuals

Szabolcs Kéri1,2, Imola Seres2, Oguz Kelemen3 and György Benedek4
2 Department of Psychiatry and Psychotherapy, Semmelweis University, Balassa u. 6., Budapest H1083, Hungary
3 Psychiatry Center, Bács-Kiskun County Hospital, Kecskemét, Hungary
4 Department of Physiology, University of Szeged, Szeged, Hungary

1 To whom correspondence should be addressed; tel: +36-20-448-3530, fax: +36-210-0336, e-mail: keriszabolcs{at}psych.sote.hu.

Background: Previous studies reported an association between weak habituation of skin conductance orienting response and psychosis proneness. The aim of this study was to investigate the relationship among neuregulin 1 (NRG1)–stimulated AKT phosphorylation (a putative marker of psychosis), orienting response habituation, delusional ideas, anxiety, and depression in nonclinical individuals. Methods: One hundred twenty individuals participated in the skin conductance measurements. Weak and strong habituators were compared on measures of NRG1-stimulated AKT phosphorylation in B lymphoblasts, delusional ideas, anxiety, and depression. The predictors of delusional ideas were determined by multiple regression analysis. Results: Weak habituators displayed higher levels of delusional ideas/anxiety and a lower ratio of phosphorylated AKT as compared with strong habituators. There were 3 significant predictors of delusional ideas: decreased habituation, NRG1-induced AKT phosphorylation, and anxiety. Age, gender, education, IQ, and depression did not predict delusional ideas. Conclusions: These results suggest that decreased habituation of arousal, NRG1-induced AKT phosphorylation, and anxiety are related to delusional ideation in the general population.

Keywords: neuregulin 1 / AKT / psychosis proneness / delusional ideation / skin conductance / orienting response


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