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Schizophrenia Bulletin Advance Access originally published online on November 10, 2006
Schizophrenia Bulletin 2007 33(1):19-20; doi:10.1093/schbul/sbl052
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© The Author 2006. Published by Oxford University Press on behalf of the Maryland Psychiatric Research Center. All rights reserved. For permissions, please email: journals.permissions@oxfordjournals.org.

Introduction: The Use of Endophenotypes to Deconstruct and Understand the Genetic Architecture, Neurobiology, and Guide Future Treatments of The Group of Schizophrenias

David L. Braff, MD
Director, Consortium on the Genetics of Schizophrenia (COGS)

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This issue of Schizophrenia Bulletin includes a series of articles on the "endophenotype strategy" to explore and understand the genetics of "schizophrenia." Initially, an atheoretical search for associations between the qualitative diagnostic disorder schizophrenia and regions of the genome was a useful first step in the high-risk voyage of discovery seeking genes conveying vulnerability to schizophrenia. However, with a huge ocean of 3 000 000 000 base pairs harboring 25 . . . [Full Text of this Article]


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