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Schizophrenia Bulletin Advance Access originally published online on May 14, 2008
Schizophrenia Bulletin 2008 34(4):587-590; doi:10.1093/schbul/sbn041
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© The Author 2008. Published by Oxford University Press on behalf of the Maryland Psychiatric Research Center. All rights reserved. For permissions, please email: journals.permissions@oxfordjournals.org.

Current Psychopathological Issues in Psychosis: Towards a Phenome-wide Scanning Approach

The first 150 words of the full text of this article appear below.


   Introduction
 
Two main pillars are essential for advancement in the understanding of complex illnesses such as schizophrenia and bipolar disorders. While the main advances in medicine and neuroscience currently come from progress in discovering new causal pathways or pathophysiological mechanisms, what is also needed, but often neglected, is parallel progress in refining the clinical paradigm.

In this respect, the original clinically based Kraepelinian distinction between dementia praecox and manic-depressive illness endures in the current classification systems of psychosis. Also, despite the fact that it continues to be the focus of much criticism,1 it still persists as the prevailing clinical model for neurobiological research.

Three main changes have notably modified the corresponding modern terms of the Kraepelinian dichotomy. First, Kraepelin's earlier unitary concept of manic depression, which included manic, circular, as well as recurrent depressive conditions, was changed to clearly differentiate bipolar from unipolar major depressive disorders.2 Second, Jaspers’ hierarchical . . . [Full Text of this Article]


   Empirical Data Support Multidimensional and Polydiagnostic Models of Psychopathology in Psychosis
 

   The Future of Psychopathology in "Genetic Times"
 

   Funding
 

Manuel J. Cuesta1,2 and Victor Peralta2
2 Psychiatric Unit, Virgen del Camino Hospital, c/ Irunlarrea 4, E-31008 Pamplona, Spain

1 To whom correspondence should be addressed; tel/fax: +34-848-422488; e-mail: mcuestaz@cfnavarra.es.


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