© 2000 by Oxford University Press and the Maryland Psychiatric Research Center (MPRC)
Neurocognitive Deficits and Functional Outcome in Schizophrenia: Are We Measuring the "Right Stuff"?
Department of Psychiatry and Behavioral Sciences, University of California Los Angeles (UCLA)
Department of Psychiatry, University of California San Diego
Department of Psychiatry and Behavioral Sciences, UCLA
Reprint requests should be sent to Dr. M.F. Green, UCLA Neuropsychiatric Institute, 760 Westwood Plaza, C9-420, Los Angeles, CA 90024–1759.
There has been a surge of interest in the functional consequences of neurocognitive deficits in schizophrenia. The published literature in this area has doubled in the last few years. In this paper, we will attempt to confirm the conclusions from a previous review that certain neurocognitive domains (secondary verbal memory, immediate memory, executive functioning as measured by card sorting, and vigilance) are associated with functional outcome. In addition to surveying the number of replicated findings and tallying box scores of results, we will approach the review of the studies in a more thorough and empirical manner by applying a meta-analysis. Lastly, we will discuss what we see as a key limitation of this literature, specifically, the relatively narrow selection of predictor measures. This limitation has constrained identification of mediating variables that may explain the mechanisms for these relationships.
Keywords: Schizophrenia / neurocognition / functional outcome / social cognition / learning potential
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