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Schizophrenia Bulletin 2001 27(3):477-480;
© 2001 by Oxford University Press and the Maryland Psychiatric Research Center (MPRC)
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© Oxford University Press

At Issue: Stress, Hippocampal Neuronal Turnover, and Neuropsychiatric Disorders

Celso Arango, M.D., Research Assistant Professor of Psychiatry, Brian Kirkpatrick, M.D., Professor of Psychiatry and James Koenig, Ph.D., Associate Professor of Psychiatry
Maryland Psychiatric Research Center, Department of Psychiatry, University of Maryland Baltimore, MD
Maryland Psychiatric Research Center, Department of Psychiatry, University of Maryland Baltimore, MD
Maryland Psychiatric Research Center, Department of Psychiatry, University of Maryland Baltimore, MD

Send reprint requests to Dr. C. Arango, MPRC, PO Box 21247, Baltimore, MD 21228; e-mail: carango{at}mprc.umaryland.edu

Stress-induced changes in the glucocorticoid system may be toxic for hippocampal cells in animals. Recently, neurogenesis has been shown in the rat, the primate, and the human hippocampus. Because chronic stress is associated with some neuropsychiatric disorders, including schizophrenia, it is possible that an imbalance in the normal turnover of hippocampal cells plays a role in the pathophysiology not only of schizophrenia but also of other neuropsychiatric disorders that involve high levels of stress. New therapeutic possibilities arise if such a process is proven to occur.

Keywords: Schizophrenia / neurodegeneration / neurogenesis / cortisol / stress / hippocampus


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