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Schizophrenia Bulletin Advance Access originally published online on February 15, 2006
Schizophrenia Bulletin 2006 32(2):305-306; doi:10.1093/schbul/sbj057
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© The Author 2006. Published by Oxford University Press on behalf of the Maryland Psychiatric Research Center. All rights reserved. For permissions, please email: journals.permissions@oxfordjournals.org.

Medication-Free Research in Early Episode Schizophrenia: Why on Earth Would I Choose to Participate in Such Research?

James McNulty1,2
2 President Emeritus, National Alliance on Mental Illness

1To whom correspondence should be addressed; e-mail: jmcnulty{at}nami.org.

The author concurs with Bola's conclusion that "a categorical prohibition of medication-free research in early episode schizophrenia on the ethical grounds of harm to human subjects should probably be reconsidered" on a case-by-case basis. The point that informed choice is rarely considered in the informed consent process is made. Several recommendations are made on how to augment the informed consent process and enhance the decision making of research participants.

Keywords: informed choice / informed consent / risk-benefit / decisionally impaired / greater than minimal risk research


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