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Schizophrenia Bulletin Advance Access originally published online on February 7, 2007
Schizophrenia Bulletin 2007 33(6):1319-1323; doi:10.1093/schbul/sbm001
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© The Author 2007. Published by Oxford University Press on behalf of the Maryland Psychiatric Research Center. All rights reserved. For permissions, please email: journals.permissions@oxfordjournals.org.

Failure to Find P50 Suppression Deficits in Young First-Episode Patients With Schizophrenia and Clinically Unaffected Siblings

O. M. de Wilde1,2, L. J. Bour3, P. M. Dingemans2, J. H. T. M. Koelman3 and D. H. Linszen2
2 Department of Psychiatry
3 Department of Neurology/Clinical Neurophysiology, Academic Medical Centre, University of Amsterdam, Tafelbergweg 25, 1105 BC, Amsterdam, The Netherlands

1 To whom correspondence should be addressed; tel: +31 (0)20-5662231, fax: +31 (0)20-5667072, e-mail: o.dewilde{at}amc.uva.nl.

Objective: To evaluate whether the P50 gating deficit is present in young first-episode patients with schizophrenia and their healthy young siblings. Methods: An auditory paired-click paradigm was used to assess P50 gating in 53 patients, 27 unaffected siblings, and 28 healthy controls. P50 parameters were compared between patients, sibs, and unrelated controls by a mixed-effects regression model. Results: P50 gating was not significantly impaired in patients with schizophrenia and healthy siblings as compared with controls. Conclusions: P50 gating was not found to be significantly impaired in young first-episode schizophrenia patients and in healthy young siblings. These results are in contrast with the existing literature. We suggest that P50 gating impairment may be developmentally or age dependent.

Keywords: early psychosis / neurophysiology / relatives / endophenotype


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