Schizophrenia Bulletin Advance Access originally published online on February 4, 2009
Schizophrenia Bulletin 2009 35(2):381-382; doi:10.1093/schbul/sbn183
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© The Author 2009. Published by Oxford University Press on behalf of the Maryland Psychiatric Research Center. All rights reserved. For permissions, please email: journals.permissions@oxfordjournals.org.
Schizophrenia as A Systemic Disease
2 Department of Psychiatry, Medical College of Georgia, Psychiatry and Health Behavior, MCG FG2227, 1515 Pope Avenue, Augusta, GA 30912
Keywords: movement disorders / inflammation / physical anomalies / diabetes / cognitive impairment
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Although in the Diagnostic and Statistical Manual of Mental Disorders of the American Psychiatric Association (DSM) schizophrenia is listed as a psychotic disorder, DSM criteria include negative symptoms and psychomotor abnormalities as well as hallucinations, delusions, and disorganization. In recent years, the concept that cognitive impairment—problems in memory, attention, executive function, etc—is also inherent to schizophrenia is gaining acceptance, and cognitive markers are now used as endophenotypes to explore the genetics of schizophrenia.
If the concept of schizophrenia extends beyond psychosis and negative symptoms, how
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1 To whom correspondence should be addressed; tel: 706-721-9852, fax: 706-721-9852, e-mail: bkirkpatrick2@aol.com.