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Schizophrenia Bulletin Advance Access published online on February 16, 2005
Schizophrenia Bulletin, doi:10.1093/schbul/sbi004
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Schizophrenia Bulletin vol. 31 no. 1 © The Author 2005. Published by Oxford University Press, on behalf of the Maryland Psychiatric Research Center. All rights reserved. For Permissions, please email: journals.permissions@oupjournals.org

Article

Symptoms Versus Neurocognitive Test Performance as Predictors of Psychosocial Status in Schizophrenia: A 1- and 4-Year Prospective Study

Matthew M. Kurtz 1*, Paul J. Moberg 2, J. Daniel Ragland 2, Ruben C. Gur 3, and Raquel E. Gur 4
1 Neuropsychologist, Schizophrenia Rehabilitation Program and Neuropsychiatry Research Center, Institute of Living, Hartford, CT; and Assistant Clinical Professor of Psychiatry, Yale School of Medicine, New Haven, CT
2 Associate Professor of Neuropsychology, Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia, PA
3 Professor, Department of Psychiatry, Neurology, and Radiology; and Director of the Brain-Behavior Laboratory, University of Pennsylvania School of Medicine
4 Professor, Department of Psychiatry, Neurology, and Radiology; and Director of the Neuropsychiatry Section, University of Pennsylvania School of Medicine

* To whom correspondence should be addressed.
Matthew M. Kurtz, E-mail: mkurtz{at}harthosp.org


  Abstract

In recent years, a growing body of literature has highlighted the significance of neurocognitive deficits as markers for subsequent psychosocial deficits in patients with schizophrenia. Relatively few studies, however, have directly compared symptoms and neurocognitive test performance as predictors of psychosocial status in a prospective design. In two studies with schizophrenia patients, we investigated the relationship between symptom dimensions (psychomotor poverty, disorganization, reality distortion) and neurocognitive measures (problem solving, attention, verbal learning and memory) obtained at study entry, and psychosocial status measured at a 1- and 4-year followup. Results from the 1-year followup (n = 70) revealed that psychomotor poverty, symptoms of disorganization, and performance on measures of card-sorting and visual vigilance were related to psychosocial status. Results from the 4-year followup (n = 26) revealed a similar pattern of findings with the exception of verbal learning, which emerged as a predictor of psychosocial status only at the 4-year followup. Stepwise regression revealed that performance on measures of visual vigilance and psychomotor poverty symptoms explained the largest amount of variance in psychosocial status at both followup intervals. The significance of these findings for the development and assessment of novel treatment interventions for schizophrenia is discussed.

Keywords: Schizophrenia; neurocognition; symptoms; quality of life.
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