Schizophrenia Bulletin Advance Access published online on February 16, 2005
Schizophrenia Bulletin, doi:10.1093/schbul/sbi014
| ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
* To whom correspondence should be addressed. Our study investigated premorbid functioning, course, and outcome in early-onset schizophrenia. All inpatients with DSM-III-R diagnoses of schizophrenia (n = 101) consecutively admitted between 1983 and 1988 to the Department of Child and Adolescent Psychiatry at the University of Marburg in Germany were included. To assess premorbid adaptation and precursor symptoms, we administered the Instrument for the Retrospective Assessment of the Onset of Schizophrenia, which we modified to assess children and adolescents. Symptomatology was measured by the Scale for the Assessment of Negative Symptoms, the Scale for the Assessment of Positive Symptoms, and the Brief Psychiatric Rating Scale. In addition, the Global Assessment of Functioning was applied. Followup data for 81 patients (80.2%) were available. The mean duration of schizophrenia at followup was 9.5 ± 2.2 years. Assessment of the highest level of adaptive functioning revealed very good or good outcome in 19.8 percent of the patients, fair or poor outcome in 38.2 percent, and very poor outcome and gross impairment in 42.0 percent. Premorbid adjustment was the best predictor of outcome in our schizophrenia sample. A poor prognosis was found in patients with premorbid developmental delays and those who were introverted and withdrawn before their psychotic state.
Article
Long-Term Course of Adolescent Schizophrenia
1 Consultant, Department of Child and Adolescent Psychiatry, Albert Ludwigs University, Freiburg, Germany
2
Professor of Child and Adolescent Psychiatry and Head, Department of Child and Adolescent Psychiatry, Albert Ludwigs University
3
Physician, Department of Child and Adolescent Psychiatry, Philipps University, Marburg, Germany
4
Professor of Child and Adolescent Psychiatry, Department of Child and Adolescent Psychiatry, Philipps University
5
Consultant, Department of Child and Adolescent Psychiatry, Albert Ludwigs University
6
Professor of Child and Adolescent Psychiatry and Head, Department of Child and Adolescent Psychiatry, Philipps University
Christian Fleischhaker, E-mail: fleischhaker{at}psyallg.ukl.uni-freiburg.de
Abstract 
CiteULike 
Connotea 
Del.icio.us What's this?
This article has been cited by other articles:
|
|
 |
|
  R. G. Ross New Findings on Antipsychotic Use in Children and Adolescents With Schizophrenia Spectrum Disorders Am J Psychiatry, November 1, 2008; 165(11): 1369 - 1372. [Full Text] [PDF]
|
|
|
|
|
|
L. Sikich, J. A. Frazier, J. McClellan, R. L. Findling, B. Vitiello, L. Ritz, D. Ambler, M. Puglia, A. E. Maloney, E. Michael, et al. Double-Blind Comparison of First- and Second-Generation Antipsychotics in Early-Onset Schizophrenia and Schizo-affective Disorder: Findings From the Treatment of Early-Onset Schizophrenia Spectrum Disorders (TEOSS) Study Am J Psychiatry, November 1, 2008; 165(11): 1420 - 1431. [Abstract] [Full Text] [PDF]
|
|