Skip Navigation



Schizophrenia Bulletin Advance Access published online on November 30, 2005
Schizophrenia Bulletin, doi:10.1093/schbul/sbj030
This Article
Right arrow Full Text (Rapid PDF)
Right arrow All Versions of this Article:
32/2/332    most recent
sbj030v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Google Scholar
Right arrow Articles by Sim, K.
Right arrow Articles by Heckers, S.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Sim, K.
Right arrow Articles by Heckers, S.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

© The Author 2005. Published by Oxford University Press on behalf of the Maryland Psychiatric Research Center. All rights reserved. For permissions, please email: journals.permissions@oxfordjournals.org.

Article

Hippocampal and Parahippocampal Volumes in Schizophrenia: A Structural MRI Study

Kang Sim 1 *, Iain DeWitt 2, Tali Ditman 2, Martin Zalesak 2, Ian Greenhouse 3, Donald Goff 4, Anthony P. Weiss 5, and Stephan Heckers 6
1 Schizophrenia and Bipolar Disorders Unit, McLean Hospital, Belmont, MA; Institute of Mental Health/Woodbridge Hospital, Singapore
2 Athinoula A. Martinos Center for Biomedical Imaging, Charlestown, MA
3 Schizophrenia and Bipolar Disorders Unit, McLean Hospital, Belmont, MA
4 Department of Psychiatry, Massachusetts General Hospital, Boston, MA
5 Athinoula A. Martinos Center for Biomedical Imaging, Charlestown, MA; Department of Psychiatry, Massachusetts General Hospital, Boston, MA
6 Schizophrenia and Bipolar Disorders Unit, McLean Hospital, Belmont, MA; Athinoula A. Martinos Center for Biomedical Imaging, Charlestown, MA; Department of Psychiatry, Massachusetts General Hospital, Boston, MA

* To whom correspondence should be addressed.
Kang Sim, E-mail: ksim{at}mclean.harvard.edu; kang_sim@imh.com.sg


  Abstract

Smaller medial temporal lobe volume is a frequent finding in studies of patients with schizophrenia, but the relative contributions of the hippocampus and three surrounding cortical regions (entorhinal cortex, perirhinal cortex, and parahippocampal cortex) are poorly understood. We tested the hypothesis that the volumes of medial temporal lobe regions are selectively changed in schizophrenia. We studied 19 male patients with schizophrenia and 19 age-matched male control subjects. Hippocampal and cortical volumes were estimated using a three-dimensional morphometric protocol for the analysis of high-resolution structural magnetic resonance images, and repeated measures ANOVA was used to test for region-specific differences. Patients had smaller overall medial temporal lobe volumes compared to controls. The volume difference was not specific for either region or hemisphere. The finding of smaller medial temporal lobe volumes in the absence of regional specificity has important implications for studying the functional role of the hippocampus and surrounding cortical regions in schizophrenia.

Keywords: medial temporal lobe; entorhinal; perirhinal; parahippocampal; region; functional.
Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 Schizophr BullHome page
B. I. Turetsky, C.-G. Hahn, K. Borgmann-Winter, and P. J. Moberg
Scents and Nonsense: Olfactory Dysfunction in Schizophrenia
Schizophr Bull, November 1, 2009; 35(6): 1117 - 1131.
[Abstract] [Full Text] [PDF]

Home page
 Schizophr BullHome page
M. J. Coleman, D. Titone, O. Krastoshevsky, V. Krause, Z. Huang, N. R. Mendell, H. Eichenbaum, and D. L. Levy
Reinforcement Ambiguity and Novelty Do Not Account for Transitive Inference Deficits in Schizophrenia
Schizophr Bull, May 21, 2009; (2009) sbp039v1.
[Abstract] [Full Text] [PDF]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.