Skip Navigation



Schizophrenia Bulletin Advance Access published online on November 30, 2005
Schizophrenia Bulletin, doi:10.1093/schbul/sbj031
This Article
Right arrow Full Text (Rapid PDF)
Right arrow All Versions of this Article:
32/1/26    most recent
sbj031v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Google Scholar
Right arrow Articles by Shore, D.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Shore, D.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

© The Author 2005. Published by Oxford University Press on behalf of the Maryland Psychiatric Research Center. All rights reserved. For permissions, please email: journals.permissions@oxfordjournals.org.

Article

Ethical Issues in Schizophrenia Research: A Commentary on Some Current Concerns

David Shore 1 *
1 Georgetown University and NIMH

* To whom correspondence should be addressed.
David Shore, E-mail: DShore{at}mail.nih.gov


  Abstract

An essential aspect of research on schizophrenia is ensuring that worthwhile scientific studies are done in a way that does not place vulnerable individuals at unreasonable risk. It is important to educate researchers, advocates, potential participants, reviewers, IRBs, and the general public about ethical principles and controversial issues as they impact research on schizophrenia. Federal regulations mandate IRB consideration of "the special problems of research involving... mentally disabled persons..." (45CFR46.111a3). In recent years, there has been a greater focus on subject monitoring to improve safeguards and minimize risks. The process of informed consent is also going through a process of evolution, in order to help ensure that participants are as aware as possible of key aspects of a study, including risks, benefits, alternatives, purpose and design, etc. We focus here on a few of the issues that are current, are relevant to schizophrenia research, and merit additional empirical study. They include medication discontinuation and placebo control designs, compensation for participation, and capacity to consent.

Keywords: research ethics; schizophrenia; placebo; consent capacity.
Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 Schizophr BullHome page
L. B. Dunn, D. S. Kim, I. E. Fellows, and B. W. Palmer
Worth the Risk? Relationship of Incentives to Risk and Benefit Perceptions and Willingness to Participate in Schizophrenia Research
Schizophr Bull, February 14, 2008; (2008) sbn003v1.
[Abstract] [Full Text] [PDF]

Home page
 Schizophr BullHome page
D. V. Jeste, B. W. Palmer, S. Golshan, L. T. Eyler, L. B. Dunn, T. Meeks, D. Glorioso, I. Fellows, H. Kraemer, and P. S. Appelbaum
Multimedia Consent for Research in People With Schizophrenia and Normal Subjects: a Randomized Controlled Trial
Schizophr Bull, January 31, 2008; (2008) sbm148v1.
[Abstract] [Full Text] [PDF]

Home page
 J Am Psychiatr Nurses AssocHome page
M. L. Spath
Continued Controversies: Issues in Mental Health Research and Implications for Nursing
Journal of the American Psychiatric Nurses Association, September 1, 2007; 13(4): 221 - 229.
[Abstract] [PDF]


Disclaimer:
Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.