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Schizophrenia Bulletin Advance Access published online on June 7, 2006
Schizophrenia Bulletin, doi:10.1093/schbul/sbl002
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© The Author 2006. Published by Oxford University Press on behalf of the Maryland Psychiatric Research Center. All rights reserved. For permissions, please email: journals.permissions@oxfordjournals.org.

Article

Does Self-perceived Mood Predict More Variance in Cognitive Performance Than Clinician-Rated Symptoms in Schizophrenia?

Rozmin Halari 1 *, Ravi Mehrotra 2, Tonmoy Sharma 3, and Veena Kumari 1
1 Department of Psychology, Centre for Social, Genetic and Developmental Psychiatry, Institute of Psychiatry, PO 46, De Crespigny Park, London SE5 8AF, UK
2 West Middlesex Hospital, West London Mental Health Trust, London, UK
3 Clinical Neuroscience Research Centre, Dartford, UK

* To whom correspondence should be addressed.
Rozmin Halari, E-mail: r.halari{at}iop.kcl.ac.uk


  Abstract

Symptoms are known to account for a small variance in some cognitive functions in schizophrenia, but the influence of self-perceived mood remains largely unknown. The authors examined the influence of subjective mood states, psychopathology, and depressive symptoms in cognitive performance in a single investigation in schizophrenia. A group of 40 stable medicated patients with schizophrenia (20 men, 20 women) and 30 healthy comparison subjects (15 men, 15 women) were assessed on neurocognitive measures of verbal abilities, attention, executive functioning, language, memory, motor functioning, and information processing. All subjects provided self-ratings of mood prior to cognitive testing. Patients were also rated on psychopathology and depressive symptoms. Patients performed worse than comparison subjects on most cognitive domains. Within the patient group, subjective feelings of depression-dejection, fatigue-inertia, confusion, and tension-anxiety predicted (controlling for symptoms) poor performance on measures of attention, executive function, and verbal memory. In the same group of patients, clinician-rated symptoms of psychopathology and depression predicted significantly poor performance only on tests of motor function. In comparison subjects, vigor related to better, and fatigue and inertia to worse, spatial motor performance. Self-perceived negative mood state may be a better predictor of cognitive deficits than clinician-rated symptoms in chronic schizophrenia patients.

Keywords: profile of mood states; schizophrenia; depression; cognitive; humans; psychopathology.
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